DPTN

Key Product Details

Product Description

DPTN is a potent and selective A₃ adenosine receptor antagonist (K_i values are in the range 0.36 - 1.65 nM (hA₃AR) and 1.6 - 8.53 nM (rA₃AR)). Reduces intrapulmonary pressure when combined with Dexamethasone (Cat. No. 1126). Readily crosses the blood brain barrier in rats.

Product Specifications for DPTN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DPTN

The following data is based on the product molecular weight 459.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.88 mL	54.42 mL	108.84 mL
1 mM	2.18 mL	10.88 mL	21.77 mL
2 mM	1.09 mL	5.44 mL	10.88 mL
10 mM	0.22 mL	1.09 mL	2.18 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Suresh Selective A3 adenosine receptor antagonist radioligand for human and rodent species. ACS Med.Chem.Lett. 2022 PMID: 35450351
• Gao Pharmacological characterization of DPTN and other selective A₃ adenosine receptor antagonists. Purinergic Signal. 2021 PMID: 34713378

Product Documents for DPTN