Noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50
values are 2.7, 8.5, 121, 153, 198 and 206 μ
M, respectively). Reduces frequency of channel opening.
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Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.
Acker et al.
The citations listed below are publications that use Tocris products. Selected citations for DQP 1105 include:
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