DR 4485 hydrochloride

Tocris Bioscience | Catalog # 5005

High affinity and selective 5-HT7 antagonist; orally bioavailable
Tocris Bioscience

Key Product Details

Description

High affinity and selective 5-HT7 antagonist; orally bioavailable
View all 5-HT7 Receptor Antagonists »

Product Description

DR 4485 hydrochloride is a high affinity and selective 5-HT7 antagonist (pKi = 8.14). Exhibits selectivity for 5-HT7 over other 5-HT receptors. Inhibits 5-HT-induced cAMP accumulation in HEK-293 cells expressing the 5-HT7 receptor. Orally bioavailable.

Product Specifications for DR 4485 hydrochloride

Molecular Weight

491.88

Formula

C26H28Cl2N2O.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one hydrochloride

CAS Number

402942-53-4

PubChem ID

90488996

InChI Key

QAERYGXKDZHTFR-UHFFFAOYSA-N

SMILES

ClC1=C2C(C3(CCCCN4CCC(C5=CC=C(Cl)C=C5)=CC4)CCC2)=C(NC3=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.19 100

Preparing Stock Solutions for DR 4485 hydrochloride

The following data is based on the product molecular weight 491.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.17 mL 20.33 mL
5 mM 0.41 mL 2.03 mL 4.07 mL
10 mM 0.20 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for DR 4485 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DR 4485 hydrochloride

For research use only

Citations for DR 4485 hydrochloride

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