DR 4485 hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:5005
Chemical Name:6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one hydrochloride
Product Details
Citations (1)
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Reviews
Biological Activity
High affinity and selective 5-HT7 antagonist (pKi = 8.14). Exhibits selectivity for 5-HT7 over other 5-HT receptors. Inhibits 5-HT-induced cAMP accumulation in HEK-293 cells expressing the 5-HT7 receptor. Orally bioavailable.
Technical Data
  • M.Wt:
    491.88
  • Formula:
    C26H28Cl2N2O.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    402942-53-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DR 4485 hydrochloride include:

1 Citations: Showing 1 - 1

  1. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.
    Authors: Chan Et al.
    PLoS Pathog  2016;12:e1005651

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