DREADD agonist 21

Catalog # Availability Size / Price Qty
5548/10
5548/50
Cat.No. 5548 - DREADD agonist 21 | C17H18N4 | CAS No. 56296-18-5
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Description: Potent muscarinic DREADD agonist

Chemical Name: 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Potent muscarinic DREADD agonist (pEC50 values are 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits > 10-fold higher affinity for hM1Dq and hM4Di compared to wild type receptors. Also displays little to no activity at wild type M3 receptors. Activates neurons expressing hM3Dq DREADDS and inhibits activity in neurons expressing hM4Di in vivo. Displays excellent brain permeability. Water soluble salt also available, DREADD agonist 21 hydrochloride (Cat. No. 6422).

Technical Data

M.Wt:
278.35
Formula:
C17H18N4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
56296-18-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.
    Chen et al.
    ACS Chem.Neurosci., 2015;18:476
  2. DREADD agonist 21 (C21) is an effective agonist for muscarinic-based DREADDs in vitro and in vivo.
    Thompson et al.
    ACS Pharmacol.Transl.Sci., 2018;

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Used in place of CNO
By Anonymous on 12/01/2017
Species: Mouse

Used this product in place of CNO


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