DS2

Catalog # Availability Size / Price Qty
3679/10
3679/50
DS2 | CAS No. 374084-31-8 | GABA-A Receptor Modulators
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Description: Positive allosteric modulator of GABAA receptors; displays subunit selectivity

Chemical Name: 4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide

Purity: ≥97%

Product Details
Citations (8)
Reviews

Biological Activity

Positive allosteric modulator of GABAA receptors. Potentiates GABA-evoked currents mediated by α4β3δ receptors (EC50 = 142 nM, in vitro). Displays complex selectivity profile, with selectivity for δ-containing receptors (α4/6βxδ > α1βxδ >> γ2 > α4β3 GABAA receptors). Enhances tonic currents of thalamocortical neurons in wild-type mice.

Technical Data

M.Wt:
353.83
Formula:
C18H12ClN3OS
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Desiccate at +4°C
CAS No:
374084-31-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DS2

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8 Citations: Showing 1 - 8

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