Catalog Number: 3679
Chemical Name: 4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide
Biological Activity
Positive allosteric modulator of δ-subunit containing GABAA receptors (EC50 = 142 nM for α4β3δ receptors). Displays no effects on GABA responses mediated by α4β3γ2 and α1β3γ2 receptors.
Technical Data
  • M.Wt:
    353.83
  • Formula:
    C18H12ClN3OS
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    374084-31-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus.
    Wafford et al.
    Neuropharmacology, 2009;56:182
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DS2 include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurosci 2016;36:607
  2. Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.
    Authors: Mirheydari Et al.
    Neurochem Res 2014;39:1057
  3. Synaptic GABAA receptor clustering without the γ2 subunit.
    Authors: Kerti-Szigeti Et al.
    Nat Methods 2014;34:10219

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