DS2

  ( 8 citations )    
Product Datasheet
Catalog Number:3679
Chemical Name:4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide
Product Details
Citations (8)
Reviews
Biological Activity
Positive allosteric modulator of δ-subunit containing GABAA receptors (EC50 = 142 nM for α4β3δ receptors). Displays no effects on GABA responses mediated by α4β3γ2 and α1β3γ2 receptors.
Technical Data
  • M.Wt:
    353.83
  • Formula:
    C18H12ClN3OS
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >97
  • Storage:
    Desiccate at +4°C
  • CAS No:
    374084-31-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for DS2 include:

8 Citations: Showing 1 - 8
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  1. Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors.
    Authors: Olander Et al.
    Biochem Pharmacol  2018;150:305
  2. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurosci  2016;36:607
  3. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
    Authors: Tong Et al.
    J Neurosci  2015;35:16142
  4. Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.
    Authors: Hammer Et al.
    PLoS One  2015;10:e0120239
  5. Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.
    Authors: Mirheydari Et al.
    Neurochem Res  2014;39:1057
  6. Synaptic GABAA receptor clustering without the γ2 subunit.
    Authors: Kerti-Szigeti Et al.
    Nat Methods  2014;34:10219
  7. Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function.
    Authors: Mennerick Et al.
    Psychopharmacology (Berl)  2014;231:3493
  8. Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.
    Authors: Shu Et al.
    Br J Pharmacol  2012;165:2228

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