Potent and selective inhibitor of cyclooxygenase-2 (IC50
values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo
. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor.
Gans et al.
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.
Gierse et al.
Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit.
Rossoni et al.
The citations listed below are publications that use Tocris products. Selected citations for DuP 697 include:
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