Catalog Number: 1430
Chemical Name: 5-Bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene
Biological Activity
Potent and selective inhibitor of cyclooxygenase-2 (IC50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active.
Technical Data
  • M.Wt:
    411.3
  • Formula:
    C17H12BrFO2S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    88149-94-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor.
    Gans et al.
    J.Pharmacol.Exp.Ther., 1990;254:180
  2. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.
    Gierse et al.
    Biochem.J., 1995;305:479
  3. Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit.
    Rossoni et al.
    Br.J.Pharmacol., 2002;135:1540
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DuP 697 include:

3 Citations: Showing 1 - 3
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  1. Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity.
    Authors: Gonnermann Et al.
    Oncoimmunology 2015;4:e988460
  2. Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland.
    Authors: Passafaro Et al.
    Neuroscience 2011;8:138
  3. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
    Authors: Wong Et al.
    Circ Res 2009;104:228

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