DY131
Chemical Name: N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
Purity: ≥99%
Biological Activity
DY131 is a novel selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Identification of an agonist ligand for estrogen-related receptors ERRβ/γ.
Yu and Forman
Bioorg.Med.Chem.Lett., 2005;15:1311
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Citations for DY131
The citations listed below are publications that use Tocris products. Selected citations for DY131 include:
9 Citations: Showing 1 - 9
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Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
Authors: Kang Et al.
Nat Commun 2018;9:1920
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DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice.
Authors: Huang
Invest Ophthalmol Vis Sci 2018;59(6):2623
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Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer.
Authors: Heckler Et al.
Oncotarget 2016;7:47201
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Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells.
Authors: Lu Et al.
Neuropharmacology 2015;16:21
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Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy.
Authors: Luo Et al.
Mol Endocrinol 2014;28:965
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ERRβ splice variants differentially regulate cell cycle progression.
Authors: Heckler and Riggins
Cell Cycle 2014;14:31
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Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression.
Authors: Byerly Et al.
Eur J Neurosci 2013;37:1033
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Estrogen-related receptor β deficiency alters body composition and response to restraint stress.
Authors: Byerly Et al.
BMC Physiol 2013;13:10
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Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells.
Authors: Gandhari Et al.
Mol Cell Endocrinol 2010;315:314
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