Chemical Name: N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
Biological ActivityNovel selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of an agonist ligand for estrogen-related receptors ERRβ/γ.
Yu and Forman
Citations for DY131
The citations listed below are publications that use Tocris products. Selected citations for DY131 include:
9 Citations: Showing 1 - 9
Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
Authors: Kang Et al.
Nat Commun 2018;9:1920
DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice.
Invest Ophthalmol Vis Sci 2018;59(6):2623
Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer.
Authors: Heckler Et al.
Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells.
Authors: Lu Et al.
Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy.
Authors: Luo Et al.
Mol Endocrinol 2014;28:965
ERRβ splice variants differentially regulate cell cycle progression.
Authors: Heckler and Riggins
Cell Cycle 2014;14:31
Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression.
Authors: Byerly Et al.
Eur J Neurosci 2013;37:1033
Estrogen-related receptor β deficiency alters body composition and response to restraint stress.
Authors: Byerly Et al.
BMC Physiol 2013;13:10
Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells.
Authors: Gandhari Et al.
Mol Cell Endocrinol 2010;315:314
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