Dynactin Subunit 1/DCTN1 Antibody [Biotin]

Name: Dynactin Subunit 1/DCTN1 Antibody [Biotin]
Brand: Novus Biologicals
SKU: NBP1-71829B
Price: 539 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-71829B

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Product Documents

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot, Immunoprecipitation

Label

Biotin

Antibody Source

Polyclonal Rabbit IgG

View all Dynactin Subunit 1/DCTN1 Primary Antibodies »

Product Specifications

Immunogen

The immunogen for this product maps to a region between residue 1228 to 1278 of human 150 kDa Dynein-Associated Polypeptide using the numbering given in entry NP_004073.2 (GeneID 1639).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Dynactin Subunit 1/DCTN1 Antibody [Biotin]

Application

Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Dynactin Subunit 1/DCTN1

The DCTN1 gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.

Alternate Names

DAP-150, DCTN1, DP-150, Dynactin 1, HMN7B

Gene Symbol

DCTN1

Additional Dynactin Subunit 1/DCTN1 Products

Product Documents for Dynactin Subunit 1/DCTN1 Antibody [Biotin]

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Certificate of Analysis

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Product Specific Notices for Dynactin Subunit 1/DCTN1 Antibody [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Microtubules

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