Catalog Number: 2897
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Biological Activity
Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of a new 'dynasore'.
    Thompson and McNiven
    Nat.Chem.Biol., 2006;2:355
  2. Dynasore, a cell-permeable inhibitor of Dynamin.
    Macia et al.
    Develop.Cell, 2006;10:839

The citations listed below are publications that use Tocris products. Selected citations for Dynasore include:

Showing Results 1 - 10 of 18

  1. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
    Authors: Blume Et al.
  2. eIF2α Confers Cellular Tolerance to S. aureus α-Toxin.
    Authors: Hoven Et al.
    Proc Natl Acad Sci U S A
  3. Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.
    Authors: Nimlamool Et al.
    Mol Biol Cell
  4. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Front Immunol
  5. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Eur J Cell Biol
  6. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    J Neurosci
  7. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    J Neurosci
  8. Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
    Authors: Marcello Et al.
    J Clin Invest
  9. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
    Authors: Bassani Et al.
  10. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.
    Authors: Chandrasekaran Et al.
    J Biol Chem
  11. Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.
    Authors: Zemskov Et al.
    PLoS One
  12. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina.
    Authors: Park Et al.
    J Neurosci
  13. Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells.
    Authors: Rodriguez Et al.
    Leuk Lymphoma
  14. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    Proc Natl Acad Sci U S A
  15. Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest.
    Authors: Lowther Et al.
  16. Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
    Authors: Li Et al.
    Mol Biol Cell
  17. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning.
    Authors: Kolpak Et al.
    Invest Ophthalmol Vis Sci
  18. Podosomes are present in a postsynaptic apparatus and participate in its maturation.
    Authors: Proszynski Et al.
    PLoS One
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Tocris Small Molecules
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Hydroxy Dynasore

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