Dynasore
Tocris Bioscience | Catalog # 2897
Product Description
Dynasore is a non-competitive reversible inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Dynasore blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells. Dynasore attenuates motor symptoms in an animal model of Parkinson's disease and in a cellular model of Alzheimer's disease it reduces tau protein aggregation and internalization.
Product Specifications for Dynasore
Molecular Weight
Formula
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Chemical Name
CAS Number
PubChem ID
InChI Key
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.23 | 100 |
Preparing Stock Solutions for Dynasore
The following data is based on the product molecular weight 322.32.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.10 mL | 15.51 mL | 31.03 mL |
| 5 mM | 0.62 mL | 3.10 mL | 6.21 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.10 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 164 publications citing the usage of this product.
- Soares PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding. J.Biol.Chem. 2021 PMID: 33831417
- Feng Inhibition of dynamin-related protein 1 ameliorates the mitochondrial ultrastructure via PINK1 and Parkin in the mice model of Parkinson's disease. Eur.J.Pharmacol. 2021 PMID: 34146589
- Macia Dynasore, a cell-permeable inhibitor of Dynamin. Develop.Cell
- Newton Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc.Natl.Acad.Sci.USA
- Thompson and McNiven Discovery of a new 'dynasore'. Nat.Chem.Biol. 2006 PMID: 16783339
Product Documents for Dynasore
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Dynasore
For research use only
Citations for Dynasore
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Customer Reviews for Dynasore (3)
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Species: HumanAssay Type: In VitroCell Line/Tissue: human macrophagesVerified Customer | Posted 06/24/2021We used dynasore inhibitor to investigate the mechanism underlying cellular entry of bacterial membrane vesicles. Human macrophages were treated by 20 uM dynasore for 1 h before adding the fluorescent dye-labeled vesicles for additional 2 h. The fluorescence of vesicles within macrophages was detected by using confocal microscopy. Our observation indicated that pretreatment of cells with dynasore significantly blocked the cellular entry of bacterial membrane vesicles.
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Species: RatAssay Type: In VitroCell Line/Tissue: Hippocampal neuronVerified Customer | Posted 03/26/2020100 μM, 45 min
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Species: MouseAssay Type: In VitroVerified Customer | Posted 02/02/2020Great product! It worked very well for us. We used this product to block dynamin-dependent endocytosis in our cells of interest to determine if our peptide of interest was imported by endocytosis or some other mechanism.
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