Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Biological ActivityDynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of a new 'dynasore'.
Thompson and McNiven
Dynasore, a cell-permeable inhibitor of Dynamin.
Macia et al.
Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis.
Newton et al.
Citations for Dynasore
The citations listed below are publications that use Tocris products. Selected citations for Dynasore include:
29 Citations: Showing 1 - 10
The MAP1B Binding Domain of Nav1.6 Is Required for Stable Expression at the Axon Initial Segment.
Authors: Solé Et al.
J Neurosci 2019;39:4238
Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Authors: Pitt Et al.
Mol Biol Cell 2017;28:2623
A versatile optical tool for studying synaptic GABAA receptor trafficking.
Authors: Lorenz-Guertin Et al.
J Cell Sci 2017;130:3933
The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection.
Authors: Hallstrom and McCormick
Gut Microbes 2016;7:136
Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
Authors: Blume Et al.
Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors for Herpes Simplex Virus 1 on Primary Murine Dermal Fibroblasts.
Authors: Petermann Et al.
J Virol 2015;89:9407
eIF2α Confers Cellular Tolerance to S. aureus α-Toxin.
Authors: Hoven Et al.
Proc Natl Acad Sci U S A 2015;6:383
Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1.
Authors: Khatua Et al.
Am J Physiol Cell Physiol 2015;309:C22
Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.
Authors: Nimlamool Et al.
Mol Biol Cell 2015;26:2755
Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
Authors: Niederst Et al.
Front Immunol 2015;26:205
Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
Authors: Ledonne Et al.
Mol Psychiatry 2015;20:959
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
Eur J Cell Biol 2015;10:e0131430
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
Authors: Lee Et al.
J Neurosci 2014;111:E5114
TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
Authors: Pribiag and Stellwagen
J Neurosci 2013;33:15879
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
Authors: Marcello Et al.
J Clin Invest 2013;123:2523
Orthobunyavirus entry into neurons and other mammalian cells occurs via clathrin-mediated endocytosis and requires trafficking into early endosomes.
Authors: Hollidge Et al.
J Virol 2012;86:7988
The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
Authors: Bassani Et al.
HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.
Authors: Chandrasekaran Et al.
J Biol Chem 2012;287:41481
Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool.
Authors: Lee Et al.
Proc Natl Acad Sci U S A 2012;109:E765
Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.
Authors: Rahn Et al.
PLoS One 2011;6:e25464
Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.
Authors: Zemskov Et al.
PLoS One 2011;6:e19414
A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina.
Authors: Park Et al.
J Neurosci 2011;52:2837
Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells.
Authors: Rodriguez Et al.
Leuk Lymphoma 2011;52:2169
Measurement and analysis of traction force dynamics in response to vasoactive agonists.
Authors: Yang Et al.
Integr Biol (Camb) 2011;3:663
Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
Authors: Lussier Et al.
Proc Natl Acad Sci U S A 2011;31:3077
Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest.
Authors: Lowther Et al.
Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
Authors: Li Et al.
Mol Biol Cell 2009;29:15551
Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning.
Authors: Kolpak Et al.
Invest Ophthalmol Vis Sci 2009;29:10488
Podosomes are present in a postsynaptic apparatus and participate in its maturation.
Authors: Proszynski Et al.
PLoS One 2009;106:18373
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Reviews for Dynasore
Average Rating: 5 (Based on 3 Reviews)
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We used dynasore inhibitor to investigate the mechanism underlying cellular entry of bacterial membrane vesicles. Human macrophages were treated by 20 uM dynasore for 1 h before adding the fluorescent dye-labeled vesicles for additional 2 h. The fluorescence of vesicles within macrophages was detected by using confocal microscopy. Our observation indicated that pretreatment of cells with dynasore significantly blocked the cellular entry of bacterial membrane vesicles.
100 μM, 45 min
Great product! It worked very well for us. We used this product to block dynamin-dependent endocytosis in our cells of interest to determine if our peptide of interest was imported by endocytosis or some other mechanism.