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Dynasore | CAS No. 304448-55-3 | Dynamin Inhibitors
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Description: Non-competitive dynamin inhibitor

Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide

Purity: ≥99%

Product Details
Citations (29)
Supplemental Products

Biological Activity

Dynasore is a non-competitive reversible inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Dynasore blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells. Dynasore attenuates motor symptoms in an animal model of Parkinson's disease and in a cellular model of Alzheimer's disease it reduces tau protein aggregation and internalization.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of a new 'dynasore'.
    Thompson and McNiven
    Nat.Chem.Biol., 2006;2:355
  2. Dynasore, a cell-permeable inhibitor of Dynamin.
    Macia et al.
    Develop.Cell, 2006;10:839
  3. Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis.
    Newton et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:17955

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Citations for Dynasore

The citations listed below are publications that use Tocris products. Selected citations for Dynasore include:

29 Citations: Showing 1 - 10

  1. The MAP1B Binding Domain of Nav1.6 Is Required for Stable Expression at the Axon Initial Segment.
    Authors: Solé Et al.
    J Neurosci  2019;39:4238
  2. Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
    Authors: Pitt Et al.
    Mol Biol Cell  2017;28:2623
  3. A versatile optical tool for studying synaptic GABAA receptor trafficking.
    Authors: Lorenz-Guertin Et al.
    J Cell Sci  2017;130:3933
  4. The type three secreted effector SipC regulates the trafficking of PERP during Salmonella infection.
    Authors: Hallstrom and McCormick
    Gut Microbes  2016;7:136
  5. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
    Authors: Blume Et al.
    J.Neurochem.  2016;139:396
  6. Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors for Herpes Simplex Virus 1 on Primary Murine Dermal Fibroblasts.
    Authors: Petermann Et al.
    J Virol  2015;89:9407
  7. eIF2α Confers Cellular Tolerance to S. aureus α-Toxin.
    Authors: Hoven Et al.
    Proc Natl Acad Sci U S A  2015;6:383
  8. Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1.
    Authors: Khatua Et al.
    Am J Physiol Cell Physiol  2015;309:C22
  9. Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.
    Authors: Nimlamool Et al.
    Mol Biol Cell  2015;26:2755
  10. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Front Immunol  2015;26:205
  11. Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
    Authors: Ledonne Et al.
    Mol Psychiatry  2015;20:959
  12. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Eur J Cell Biol  2015;10:e0131430
  13. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    J Neurosci  2014;111:E5114
  14. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    J Neurosci  2013;33:15879
  15. Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
    Authors: Marcello Et al.
    J Clin Invest  2013;123:2523
  16. Orthobunyavirus entry into neurons and other mammalian cells occurs via clathrin-mediated endocytosis and requires trafficking into early endosomes.
    Authors: Hollidge Et al.
    J Virol  2012;86:7988
  17. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
    Authors: Bassani Et al.
    Neuron  2012;73:1143
  18. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.
    Authors: Chandrasekaran Et al.
    J Biol Chem  2012;287:41481
  19. Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool.
    Authors: Lee Et al.
    Proc Natl Acad Sci U S A  2012;109:E765
  20. Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.
    Authors: Rahn Et al.
    PLoS One  2011;6:e25464
  21. Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.
    Authors: Zemskov Et al.
    PLoS One  2011;6:e19414
  22. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina.
    Authors: Park Et al.
    J Neurosci  2011;52:2837
  23. Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells.
    Authors: Rodriguez Et al.
    Leuk Lymphoma  2011;52:2169
  24. Measurement and analysis of traction force dynamics in response to vasoactive agonists.
    Authors: Yang Et al.
    Integr Biol (Camb)  2011;3:663
  25. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    Proc Natl Acad Sci U S A  2011;31:3077
  26. Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest.
    Authors: Lowther Et al.
    Reproduction  2011;141:737
  27. Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
    Authors: Li Et al.
    Mol Biol Cell  2009;29:15551
  28. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning.
    Authors: Kolpak Et al.
    Invest Ophthalmol Vis Sci  2009;29:10488
  29. Podosomes are present in a postsynaptic apparatus and participate in its maturation.
    Authors: Proszynski Et al.
    PLoS One  2009;106:18373


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