Catalog Number: 2897
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Biological Activity
Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of a new 'dynasore'.
    Thompson and McNiven
    Nat.Chem.Biol., 2006;2:355
  2. Dynasore, a cell-permeable inhibitor of Dynamin.
    Macia et al.
    Develop.Cell, 2006;10:839

The citations listed below are publications that use Tocris products. Selected citations for Dynasore include:

18 Citations: Showing 1 - 10
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  1. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
    Authors: Blume Et al.
    J.Neurochem. 2016;139:396
  2. eIF2α Confers Cellular Tolerance to S. aureus α-Toxin.
    Authors: Hoven Et al.
    Proc Natl Acad Sci U S A 2015;6:383
  3. Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.
    Authors: Nimlamool Et al.
    Mol Biol Cell 2015;26:2755
  4. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Front Immunol 2015;26:205
  5. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Eur J Cell Biol 2015;10:e0131430
  6. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    J Neurosci 2014;111:E5114
  7. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    J Neurosci 2013;33:15879
  8. Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
    Authors: Marcello Et al.
    J Clin Invest 2013;123:2523
  9. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
    Authors: Bassani Et al.
    Neuron 2012;73:1143
  10. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.
    Authors: Chandrasekaran Et al.
    J Biol Chem 2012;287:41481
  11. Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.
    Authors: Zemskov Et al.
    PLoS One 2011;6:e19414
  12. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina.
    Authors: Park Et al.
    J Neurosci 2011;52:2837
  13. Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells.
    Authors: Rodriguez Et al.
    Leuk Lymphoma 2011;52:2169
  14. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    Proc Natl Acad Sci U S A 2011;31:3077
  15. Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest.
    Authors: Lowther Et al.
    Reproduction 2011;141:737
  16. Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
    Authors: Li Et al.
    Mol Biol Cell 2009;29:15551
  17. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning.
    Authors: Kolpak Et al.
    Invest Ophthalmol Vis Sci 2009;29:10488
  18. Podosomes are present in a postsynaptic apparatus and participate in its maturation.
    Authors: Proszynski Et al.
    PLoS One 2009;106:18373
Expand to show all 18 Citations
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