Dynasore

  ( 21 citations )    
Product Datasheet
Catalog Number:2897
Chemical Name:3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Product Details
Citations (21)
Supplemental Products
Reviews
Biological Activity
Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
Technical Data
  • M.Wt:
    322.32
  • Formula:
    C18H14N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    304448-55-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dynasore include:

21 Citations: Showing 1 - 10
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  1. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
    Authors: Blume Et al.
    J.Neurochem.  2016;139:396
  2. eIF2α Confers Cellular Tolerance to S. aureus α-Toxin.
    Authors: Hoven Et al.
    Proc Natl Acad Sci U S A  2015;6:383
  3. Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1.
    Authors: Khatua Et al.
    Am J Physiol Cell Physiol  2015;309:C22
  4. Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.
    Authors: Nimlamool Et al.
    Mol Biol Cell  2015;26:2755
  5. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Front Immunol  2015;26:205
  6. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Eur J Cell Biol  2015;10:e0131430
  7. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    J Neurosci  2014;111:E5114
  8. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    J Neurosci  2013;33:15879
  9. Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
    Authors: Marcello Et al.
    J Clin Invest  2013;123:2523
  10. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
    Authors: Bassani Et al.
    Neuron  2012;73:1143
  11. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.
    Authors: Chandrasekaran Et al.
    J Biol Chem  2012;287:41481
  12. Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.
    Authors: Rahn Et al.
    PLoS One  2011;6:e25464
  13. Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.
    Authors: Zemskov Et al.
    PLoS One  2011;6:e19414
  14. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina.
    Authors: Park Et al.
    J Neurosci  2011;52:2837
  15. Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells.
    Authors: Rodriguez Et al.
    Leuk Lymphoma  2011;52:2169
  16. Measurement and analysis of traction force dynamics in response to vasoactive agonists.
    Authors: Yang Et al.
    Integr Biol (Camb)  2011;3:663
  17. Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
    Authors: Lussier Et al.
    Proc Natl Acad Sci U S A  2011;31:3077
  18. Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest.
    Authors: Lowther Et al.
    Reproduction  2011;141:737
  19. Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.
    Authors: Li Et al.
    Mol Biol Cell  2009;29:15551
  20. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning.
    Authors: Kolpak Et al.
    Invest Ophthalmol Vis Sci  2009;29:10488
  21. Podosomes are present in a postsynaptic apparatus and participate in its maturation.
    Authors: Proszynski Et al.
    PLoS One  2009;106:18373
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