Catalog Number: 5364
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
Biological Activity
Dynamin inhibitor (IC50 values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism.
    Harper et al.
    J.Biol.Chem., 2011;286:35966
  2. Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.
    McCluskey et al.
    Traffic, 2013;14:1272
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