Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
Biological ActivityHydroxy Dynasore is a dynamin inhibitor (IC50 values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).
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Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism.
Harper et al.
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.
McCluskey et al.
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