Selective blocker of KV
11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+
). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+
inward currents. Class III antiarrhythmic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.
Ficker et al.
Effects of the delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit.
Verheijck et al.
Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.
Wettwer et al.
The citations listed below are publications that use Tocris products. Selected citations for E-4031 dihydrochloride include:
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