E-4031 dihydrochloride

Tocris Bioscience | Catalog # 1808

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
Tocris Bioscience

Key Product Details

Description

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
View all Voltage-gated Potassium Channel Blockers »

Product Description

E-4031 dihydrochloride is a selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. Class III antiarrhythmic agent.

Product Specifications for E-4031 dihydrochloride

Molecular Weight

474.44

Formula

C21H27N3O3S.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

CAS Number

113559-13-0

PubChem ID

3087190

InChI Key

ZQBNWMFBOSOOLX-UHFFFAOYSA-N

SMILES

Cl.Cl.CC1=CC=CC(CCN2CCC(CC2)C(=O)C2=CC=C(NS(C)(=O)=O)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 47.44 100
DMSO 9.49 20 with gentle warming

Preparing Stock Solutions for E-4031 dihydrochloride

The following data is based on the product molecular weight 474.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

Product Documents for E-4031 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for E-4031 dihydrochloride

For research use only

Citations for E-4031 dihydrochloride

Customer Reviews for E-4031 dihydrochloride (2)

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  • E-4031 shortens cardiac action potential duration
    Name: Anonymous
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 05/16/2019
    A representative action potential of a guinea pig cardiomyocyte before and after perfusion with 500 nM E-4031 for 5 min and stimulated at a frequency of 1 Hz in a whole cell patch clamp model. E-4031 significantly shortened action potential duration of guinea pig ventricular cardiomyocytes.
    E-4031 dihydrochloride 1808
  • Antiarrhythmic drug E-4031 was studied to identify drug effect: Overall great product
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/22/2018
    As an antiarrhythmic drug E-4031 was studied to identify drug effect. Concentration dependent Kv channel blocking and control of release were studied. The compound showed blocking activity which is not dependent on concentration administered and data was reproducible. Great product stability and dissolves nicely.
    E-4031 dihydrochloride 1808

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