E-4031 dihydrochloride

Catalog # Availability Size / Price Qty
1808/10
1808/50
Voltage-gated Potassium Channel Blockers Small Molecule
1 Image
Description: KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Chemical Name: N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

Purity: ≥98%

Product Details
Citations (10)
Reviews (2)

Biological Activity

Selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. Class III antiarrhythmic agent.

Technical Data

M.Wt:
474.44
Formula:
C21H27N3O3S.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
113559-13-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for E-4031 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for E-4031 dihydrochloride include:

10 Citations: Showing 1 - 10

  1. Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel.
    Authors: Veldkamp Et al.
    Nat Commun  2018;9:4357
  2. Electrophysiological measurement of ion channels on plasma/organelle membranes using an on-chip lipid bilayer system.
    Authors: Kamiya Et al.
    Sci Rep  2018;8:17498
  3. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
    Authors: McKeithan Et al.
    Front Physiol  2017;8:766
  4. Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells.
    Authors: Zhang Et al.
    Stem Cell Res  2017;20:21
  5. Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells.
    Authors: Pei Et al.
    Stem Cell Res  2017;19:94
  6. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.
    Authors: Bragança Et al.
    Front Pharmacol  2016;7:45
  7. Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
    Authors: Zhang Et al.
    PLoS One  2015;8:10239
  8. Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways.
    Authors: Guo Et al.
    Curr Protoc Chem Biol  2015;7:141
  9. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
    Authors: Yu Et al.
    Int J Clin Exp Pathol  2014;9:e96691
  10. Characterization of hERG1 channel role in mouse colorectal carcinogenesis.
    Authors: Fiore Et al.
    Cancer Med  2013;2:583

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for E-4031 dihydrochloride

Average Rating: 5 (Based on 2 Reviews)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used E-4031 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


E-4031 shortens cardiac action potential duration
By Anonymous on 05/16/2019
Species: Other

A representative action potential of a guinea pig cardiomyocyte before and after perfusion with 500 nM E-4031 for 5 min and stimulated at a frequency of 1 Hz in a whole cell patch clamp model. E-4031 significantly shortened action potential duration of guinea pig ventricular cardiomyocytes.


Antiarrhythmic drug E-4031 was studied to identify drug effect: Overall great product
By Anonymous on 10/22/2018
Species: Human

As an antiarrhythmic drug E-4031 was studied to identify drug effect. Concentration dependent Kv channel blocking and control of release were studied. The compound showed blocking activity which is not dependent on concentration administered and data was reproducible. Great product stability and dissolves nicely.


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.