EBOV GP Antibody (06) [FITC]

Novus Biologicals | Catalog # NBP3-06458F

Novus Biologicals
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Key Product Details

Species Reactivity

Ebola Virus

Applications

ELISA

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 06
View all EBOV GP Primary Antibodies »

Product Specifications

Immunogen

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant EBOV GP (Accession#: AAC54887.1; Met1-Gln650).

Reactivity Notes

Ebola virus EBOV (subtype Zaire, strain Mayinga 1976)

Specificity

Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein/GP

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for EBOV GP Antibody (06) [FITC]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: EBOV GP

The GP glycoprotein encoded by the genome of Ebola family viruses is a critical molecule for the pathogenicity of Ebolavirus hemorrhagic viruses. It is processed into GP1 and GP2 fragments which remain disulfide linked. GP1 is entirely extracellular while GP2 is a transmembrane protein. GP expressed on virus infected cells can be shed by TACE mediated cleavage, liberating a disulfide linked complex of soluble GP1 and truncated GP2. GP binds to multiple C-type lectins on target cell surfaces, including CLEC10A/MGL, DC-SIGN, and DC-SIGNR. Following internalization, GP1 is cleaved by Cathepsin B and Cathepsin L and then interacts with Niemann-Pick C1 (NPC1) in the endosomal membrane.

Long Name

Ebola Virus Glycoprotein

Alternate Names

bovGP

Gene Symbol

GP

Additional EBOV GP Products

Product Documents for EBOV GP Antibody (06) [FITC]

Certificate of Analysis

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Product Specific Notices for EBOV GP Antibody (06) [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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