Catalog Number: 4011
Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid
Biological Activity
Photostable synthetic retinoid; analog of ATRA (Cat. No. 0695). Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Potently induces neural differentiation in human pluripotent embryonic stem cells.
Technical Data
  • M.Wt:
    332.44
  • Formula:
    C23H24O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    104561-41-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Reinnervate Limited, patent pending
Background References
  1. Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation.
    Christie et al.
    Org.Biomol.Chem., 2008;6:3497
  2. Synthetic retinoids: structure-activity relationships.
    Barnard et al.
    Chemistry, 2009;15:11430
  3. Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins.
    Maltman et al.
    Mol.Biosyst., 2009;5:458

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