Catalog Number: 5955
Chemical Name: 3-(2-Amino-5-benzoxazolyl)-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological Activity
Potent mTOR inhibitor (IC50 = 15 nM). Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro (EC50 = 8.5 nM). Cell permeable.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of eCF 309 is reviewed on the Chemical Probes website.
Technical Data
  • M.Wt:
    383.41
  • Formula:
    C18H21N7O3
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    2001571-40-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. eCF309: a potent, selective and cell-permeable mTOR inhibitor
    Fraser et al.
    Med.Chem.Commun., 2016;4:471
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