Potent mTOR inhibitor (IC50
= 15 nM). Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro
= 8.5 nM). Cell permeable.Chemicalprobes.org
is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of eCF 309
is reviewed on the Chemical Probes website.
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
eCF309: a potent, selective and cell-permeable mTOR inhibitor
Fraser et al.