Potent irreversible αVβ3
integrin antagonist (Ki
= 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50
= 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3
) receptors (IC50
= 30 nM) in vitro
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All Tocris products are intended for laboratory research use only.
Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins RGD-containing peptides from viper venoms.
Musial et al.
Echistatin is a potent inhibitor of bone resorption in culture.
Sato et al.
Biochemical characteriation of the binding of echistatin to integrin αVβ3 receptor.
Kumar et al.
The citations listed below are publications that use Tocris products. Selected citations for Echistatin, α1 isoform include:
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