Ectodysplasin (EDA) is a type II transmembrane protein belonging to the TNF superfamily. It can be expressed as eight alternatively spliced isoforms that are encoded by the EDA gene. Isoforms of EDA are expressed in cells of ectodermal origin, where they are localized to the cell surface and can be released in a soluble form following cleavage by Furin. The EDA-A1 and EDA-A2 splice variants differ by the deletion of two amino acids in the extracellular domain of EDA-A2. Despite this minor difference, EDA-A1 and EDA-A2 display strong receptor specificity. EDA-A1 binds to EDAR, whereas EDA-A2 binds to XEDAR. EDA-A1 and EDA-A2 are required during development, and loss or mutation of EDA results in abnormal development of hair follicles, sweat glands, and teeth. Mutations in the EDA gene are associated with a group of developmental disorders identified as ectodermal dysplasia type 1.
EDA/Ectodysplasin Antibody (Renzo-2) [Alexa Fluor™ Plus 488]
Novus Biologicals | Catalog # NBP2-59772AFP488
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Reactivity Notes
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Applications for EDA/Ectodysplasin Antibody (Renzo-2) [Alexa Fluor™ Plus 488]
ELISA
Flow Cytometry
Immunoprecipitation
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Background: EDA/Ectodysplasin
Alternate Names
Gene Symbol
Additional EDA/Ectodysplasin Products
Product Documents for EDA/Ectodysplasin Antibody (Renzo-2) [Alexa Fluor™ Plus 488]
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Product Specific Notices for EDA/Ectodysplasin Antibody (Renzo-2) [Alexa Fluor™ Plus 488]
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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