Chemical Name: 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Biological ActivityPotent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of p97-dependent protein degradation by eeyarestatin I.
Wang et al.
Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways.
Aletrari et al.
PLoS One, 2011;6:e22713
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells.
Wang et al.
Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum.
Cross et al.
J.Cell Science, 2009;122:4393
Citations for Eeyarestatin I
The citations listed below are publications that use Tocris products. Selected citations for Eeyarestatin I include:
4 Citations: Showing 1 - 4
Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species.
Authors: Eales Et al.
Sci Rep 2018;8(1):14358
Affinity Purification of the Hepatitis C Virus Replicase Identifies Valosin-Containing Protein, a Member of the ATPases Associated with Diverse Cellular Activities Family, as an Active Virus Replication Modulator.
Authors: Yi Et al.
J Virol 2016;90:9953
Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors.
Authors: Han Et al.
Cell Rep 2015;290:325
Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.
Authors: Davis Et al.
Biochem Biophys Res Commun 2015;11:1727
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