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Efonidipine hydrochloride monoethanolate

3733 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3733/10
3733/50
Efonidipine hydrochloride monoethanolate | CAS No. 111011-76-8 | Cav1.x Channel Blockers
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Description: CaV1.x and CaV3.x blocker

Chemical Name: 5-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid 2-[phenyl(phenylmethyl)amino]ethyl ester hydrochloride monoethanolate

Purity: ≥99%

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Biological Activity

Selective blocker of L-type and T-type Ca2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R(-) and S(+)-enantiomers display different channel selectivity; S(+)-Efonidipine blocks L-type and T-type channels whereas R(-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.

Technical Data

M.Wt:
714.18
Formula:
C34H38N3O7P.HCl.C2H5OH
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
111011-76-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of myocardial L- and T-type Ca2+ currents by efonidipine: possible mechanism for its chronotropic effect.
    Masumiya et al.
    Eur.J.Pharmacol., 1998;349:351
  2. Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels.
    Furukawa et al.
    Br.J.Pharmacol., 2004;143:1050
  3. A selective T-type Ca2+ channel blocker R(-) efonidipine.
    Shin et al.
    Naunyn-Schmied.Arch.Pharmacol., 2008;377:411

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