Efonidipine hydrochloride monoethanolate

Key Product Details

Product Description

Selective blocker of L-type and T-type Ca²⁺ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R(-) and S(+)-enantiomers display different channel selectivity; S(+)-Efonidipine blocks L-type and T-type channels whereas R(-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.

Product Specifications for Efonidipine hydrochloride monoethanolate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Efonidipine hydrochloride monoethanolate

The following data is based on the product molecular weight 714.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.40 mL	7.00 mL	14.00 mL
5 mM	0.28 mL	1.40 mL	2.80 mL
10 mM	0.14 mL	0.70 mL	1.40 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Furukawa Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca²⁺ channels. Br.J.Pharmacol. 2004 PMID: 15545287
• Shin A selective T-type Ca²⁺ channel blocker R(-) efonidipine. Naunyn-Schmied.Arch.Pharmacol.
• Masumiya Inhibition of myocardial L- and T-type Ca²⁺ currents by efonidipine: possible mechanism for its chronotropic effect. Eur.J.Pharmacol. 1998 PMID: 9671117

Product Documents for Efonidipine hydrochloride monoethanolate