Eletriptan hydrobromide

Catalog # Availability Size / Price Qty
3862/5
3862/25
Eletriptan hydrobromide | CAS No. 177834-92-3 | 5-HT1B Receptor Agonists
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Description: 5-HT1B and 5-HT1D agonist; orally active

Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole hydrobromide

Purity: ≥99%

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Biological Activity

Orally active, selective 5-HT1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo. Displays antimigraine activity.

Technical Data

M.Wt:
463.43
Formula:
C22H26N2O2S.HBr
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
177834-92-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Characterisation of the 5-HT receptor binding profile of eletr. and kinetics of [3H]-eletriptan binding at human 5-HT1B and 5-HT1D receptors.
    Napier et al.
    Eur.J.Pharmacol., 1999;368:259
  2. The in vivo pharmacological profile of eletr. (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist.
    Gupta et al.
    Eur.J.Pharmacol., 2000;398:73
  3. Porcine carotid vascular effects of eletr. (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity.
    Willems et al.
    Naunyn-Schmied.Arch.Pharmacol., 1998;358:212

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