EM 12-FS

Key Product Details

Product Description

EM12-FS is a selective N-terminal glutamine amidohydrolase 1 (NTAQ1) Degrader. In MOLT4 cells, it downregulates NTAQ1 via cereblon-mediated degradation (IC₅₀ = 256 nM). Requires covalent His353 engagement to recruit and degrade NTAQ1.

Product Specifications for EM 12-FS

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for EM 12-FS

The following data is based on the product molecular weight 342.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.61 mL	29.21 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cruite Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem.Biol. 2022 PMID: 36128501

Product Documents for EM 12-FS