EMD 66684

Key Product Details

Product Description

EMD 66684 is a highly potent and very selective non-peptide angiotensin AT₁ receptor antagonist (IC₅₀ values are 0.7 and > 10000 nM for AT₁ and AT₂ receptors respectively). Potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC₅₀ = 0.2 nM) and reduces blood pressure in hypertensive rats.

Product Specifications for EMD 66684

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for EMD 66684

The following data is based on the product molecular weight 547.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.66 mL	18.28 mL	36.56 mL
2.5 mM	0.73 mL	3.66 mL	7.31 mL
5 mM	0.37 mL	1.83 mL	3.66 mL
25 mM	0.07 mL	0.37 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mederski 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT₁ antagonists with improved affinity for the AT₂ receptor. Bioorg.Med.Chem.Lett.
• Mederski Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J.Med.Chem. 1994 PMID: 8201597

Product Documents for EMD 66684