EMD 66684

Catalog # Availability Size / Price Qty
1849/10
1849/50
EMD 66684 | CAS No. 1216884-39-7 | Angiotensin AT1 Receptor Antagonists
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Description: Potent and selective non-peptide AT1 antagonist

Chemical Name: 2-Butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl-4-yl]methyl]-5H-imidazo[4,5-c]pyridine-5-acetamide hydrochloride

Purity: ≥98%

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Biological Activity

Highly potent and very selective non-peptide angiotensin AT1 receptor antagonist (IC50 values are 0.7 and > 10000 nM for AT1 and AT2 receptors respectively). Potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC50 = 0.2 nM) and reduces blood pressure in hypertensive rats.

Technical Data

M.Wt:
547.05
Formula:
C28H30N8O2.HCl
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
1216884-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.
    Mederski et al.
    J.Med.Chem., 1994;37:1632
  2. 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor.
    Mederski et al.
    Bioorg.Med.Chem.Lett., 1995;5:2665

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