Chemical Name: (2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine dihydrochloride
Biological ActivityEmetine is a RNA polymerase inhibitor. It inhibits SARS-CoV-2 replication (EC50 = 460 nM) and in combination with Remdesivir (Cat. No.7226) synergistically inhibits the viral yield of SARS-CoV-2 by 64.9%. Emetine attenuates hCoV-OC43, hCoV-NL43, SARS-CoV, MERS-CoV, and MHV-A59 in vitro with EC50 values in the low micromolar range. It also inhibits replication of a broad range of RNA and DNA viruses, including influenza, ebolavirus and HIV-1. Emetine potently inhibits ZIKV replication in vitro (IC50 = 52.9 nm) and suppresses ZIKV viral load in vivo. Anti-inflammatory, antiviral, antimalarial, antibacterial and anti-amebic.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro.
Choy et al.
Antiviral Res., 2020;178
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