Selective inhibitor of p38α
that displays no activity at p38γ
, ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF-α
, IL-6, IL-1β
and IL-10 (IC50
values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis.
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All Tocris products are intended for laboratory research use only.
Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.
Ottosen et al.