Eplivanserin hemifumarate

Tocris Bioscience | Catalog # 4958

Potent and selective 5-HT2A antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective 5-HT2A antagonist

Alternative Names

SR-46349 hemifumarate,SR-46349B
View all 5-HT2A Receptor Antagonists »

Product Description

Eplivanserin hemifumarate is a potent and selective 5-HT2A antagonist (IC50 values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.

Product Specifications for Eplivanserin hemifumarate

Molecular Weight

386.42

Formula

C19H21FN2O2.0.5C4H4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(1Z,2E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime hemifumarate

CAS Number

130580-02-8

PubChem ID

6438382

InChI Key

UCLIFEBROADCQW-PWERMGERSA-N

SMILES

OC(C=C2)=CC=C2/C=C/C(C1=CC=CC=C1F)=N/OCCN(C)C.O=C(/C=C/C(O)=O)O.OC(C=C4)=CC=C4/C=C/C(C3=CC=CC=C3F)=N/OCCN(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.32 50

Preparing Stock Solutions for Eplivanserin hemifumarate

The following data is based on the product molecular weight 386.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.18 mL 25.88 mL 51.76 mL
2.5 mM 1.04 mL 5.18 mL 10.35 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
25 mM 0.10 mL 0.52 mL 1.04 mL

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Product Documents for Eplivanserin hemifumarate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Eplivanserin hemifumarate

For research use only

Citations for Eplivanserin hemifumarate

Customer Reviews for Eplivanserin hemifumarate (1)

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  • Eplivanserin hemifumarate blocks MDMA-induced striatal activation and locomotion
    Name: Kevin Ball
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/25/2019
    We assessed the effect of the 5-HT2A antagonist, SR-46349B (eplivanserin hemifumarate; 0.5 mg/kg, s.c.), on MDMA (ecstasy)-induced locomotion and dorsal striatal single-unit electrophysiology. SR-46349B blocked nearly all MDMA-induced striatal excitations, which paralleled its significant attenuation of MDMA-induced locomotor activation (shown in figure).
    Eplivanserin hemifumarate 4958

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