Catalog Number: 4276
Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Biological Activity
Potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands.
    Malamas et al.
    J.Med.Chem., 2004;47:5021
  2. Evaluaton of an estrogen receptor-β agonist in animal models of human disease.
    Harris et al.
    Endocrinology, 2003;144:4241
  3. Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes.
    Cvoro et al.
    J.Immunol., 2008;180:630
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