Recombinant Mouse ErbB2/Her2 Fc His (C-Term) Protein

Novus Biologicals | Catalog # NBP3-18207

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Key Product Details

Source

HEK293

Tag

His (C-Term)

Applications

SDS-PAGE
View all ErbB2/Her2 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a C-terminal hFc and 6xHis tag corresponding to the amino acids Thr23-Thr653 of Mouse ErbB2/Her2.

Source: HEK293

(Accession #: NP_001003817.1)

Store at -20C to -80C long term. After reconstitution, the product is stable at -20C for 3 months, and 2-8C for up to 1 week.

Purity

>97%, by SDS-PAGE

Endotoxin Level

< 0.1 EU/ug of the protein by LAL method

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Mouse ErbB2/Her2 Fc His (C-Term) Protein

SDS-PAGE: Recombinant Mouse ErbB2/Her2 Fc His (C-Term) Protein [NBP3-18207]

SDS-PAGE: Recombinant Mouse ErbB2/Her2 Fc His (C-Term) Protein [NBP3-18207]

SDS-Page: Recombinant Mouse ErbB2/Her2 Fc His (C-Term) Protein [NBP3-18207] - Recombinant Mouse ErbB2/Her2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 120-140 kDa.

Formulation, Preparation, and Storage

NBP3-18207
Formulation Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4
Concentration Lyoph
Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: ErbB2/Her2

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Long Name

Receptor Tyrosine Protein Kinase ErbB2

Alternate Names

CD340, HER2, Neu Oncogene, NGL, TKR1

Gene Symbol

ERBB2

Additional ErbB2/Her2 Products

Product Documents for Recombinant Mouse ErbB2/Her2 Fc His (C-Term) Protein

Certificate of Analysis

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Product Specific Notices for Recombinant Mouse ErbB2/Her2 Fc His (C-Term) Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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FAQs for Recombinant Mouse ErbB2/Her2 Fc His (C-Term) Protein

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  • Q: I am interested in getting antibodies for HER that would work in flow cytometry. Could you recommend some choices?

    A: A list of our ErbB2 antibodies validated for use in flow cytometry can be found here /productsearch/HER2#fq=common_name%3A%22ErbB2%2FHER2%22&fq=category%3A%22Primary%20Antibodies%22&fq=applications%3A%22Flow%20Cytometry%22

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