ErbB3/Her3 [p Tyr1289] Antibody (0004) - Azide and BSA Free

Novus Biologicals | Catalog # NBP3-30737

Recombinant Monoclonal Antibody
Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Cynomolgus Monkey (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 0004 expressed in HEK293

Format

Azide and BSA Free
View all ErbB3/Her3 Primary Antibodies »

Product Specifications

Immunogen

This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Tyr1289 of the Human ErbB3/Her3

Modification

p Tyr1289

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ErbB3/Her3 [p Tyr1289] Antibody (0004) - Azide and BSA Free

ErbB3/Her3 [p Tyr1289] Antibody (0004)

Western Blot: ErbB3/Her3 [p Tyr1289] Antibody (0004) [NBP3-30737] -

Western Blot: ErbB3/Her3 [p Tyr1289] Antibody (0004) [NBP3-30737] - Western blot analysis of extracts from serum-starved MCF-7, untreated (-) or treated with neuregulin-1 (100 ng/mL, 5 min) using (Cat# NBP3-30737) at 1:2000 dilution (upper), or Rabbit Polyclonal HER3/ERBB3 Antibody at 1:2000 dilution (middle), or Mouse Monoclonal Beta-Tubulin Loading Control Antibody at 1:2000 dilution (lower)
ErbB3/Her3 [p Tyr1289] Antibody (0004) - Azide and BSA Free

Western Blot: ErbB3/Her3 [p Tyr1289] Antibody (0004) [NBP3-30737] -

Western Blot: ErbB3/Her3 [p Tyr1289] Antibody (0004) [NBP3-30737] - Western blot analysis of extracts from serum-starved MCF-7, untreated (line A); treated with neuregulin-1 (100ng/ml, 5min; +) (line B); treated with neuregulin-1 and -phosphatase (line C) using NBP3-30737 at 1:100000 dilution.

Applications for ErbB3/Her3 [p Tyr1289] Antibody (0004) - Azide and BSA Free

Application
Recommended Usage

Western Blot

1:2000-1:20000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ErbB3/Her3

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Long Name

Receptor Tyrosine Protein Kinase ErbB3

Alternate Names

HER3

Gene Symbol

ERBB3

Additional ErbB3/Her3 Products

Product Documents for ErbB3/Her3 [p Tyr1289] Antibody (0004) - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for ErbB3/Her3 [p Tyr1289] Antibody (0004) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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