Chemical Name: 1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol
Biological ActivityERGi-USU is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth.
Mohamed et al.
Cancer Res., 2018;78:3659
Citation for ERGi-USU
The citations listed below are publications that use Tocris products. Selected citations for ERGi-USU include:
1 Citation: Showing 1 - 1
Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer.
Authors: Marc Et al.
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