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ERGi-USU | CAS No. 1147-56-4 | Other Kinase Inhibitors
1 Image
Description: Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein

Chemical Name: 1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol

Purity: ≥99%

Product Details

Biological Activity

ERGi-USU is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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