Non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC50
values are 53 and >100 μ
M for COX-2 and COX-1 respectively). Displays anti-inflammatory effects in both adjuvant arthritic and normal rats.
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All Tocris products are intended for laboratory research use only.
Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes.
Kato et al.
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
Tachibana et al.
Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats.
Shi et al.
Acta Pharmacol.Sinica, 2004;25:996