Catalog Number: 3871
Chemical Name: (RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
Biological Activity
Non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC50 values are 53 and >100 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory effects in both adjuvant arthritic and normal rats.
Technical Data
  • M.Wt:
    287.35
  • Formula:
    C17H21NO3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
    41340-25-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes.
    Kato et al.
    J.Pharm.Pharmacol., 2001;53:1679
  2. Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
    Tachibana et al.
    Pharmacology, 2003;68:96
  3. Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats.
    Shi et al.
    Acta Pharmacol.Sinica, 2004;25:996
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