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Etodolac

Catalog #: 3871 Datasheet / COA / SDS

Discontinued Product

3871 has been discontinued.
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Etodolac | CAS No. 41340-25-4 | Cyclooxygenase Inhibitors
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Description: Selective cyclooxygenase-2 (COX-2) inhibitor; NSAID

Chemical Name: (RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid

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Biological Activity

Non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC50 values are 53 and >100 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory effects in both adjuvant arthritic and normal rats.

Technical Data

M.Wt:
287.35
Formula:
C17H21NO3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
41340-25-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes.
    Kato et al.
    J.Pharm.Pharmacol., 2001;53:1679
  2. Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
    Tachibana et al.
    Pharmacology, 2003;68:96
  3. Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats.
    Shi et al.
    Acta Pharmacol.Sinica, 2004;25:996

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⚠ WARNING: This product can expose you to chemicals including Etodolac, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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