Catalog Number: 1471
Chemical Name: (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
Biological Activity
General anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.
Technical Data
  • M.Wt:
    244.29
  • Formula:
    C14H16N2O2
  • Solubility:
    Soluble to 100 mM in ethanol and to 50 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    33125-97-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid.
    Belelli et al.
    Proc.Natl.Acad.Sci.U.S.A., 1997;94:11031
  2. Etomidate: a new intravenous anesthetic induction agent.
    Giese et al.
    Pharmacother., 1983;3:251
  3. Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABAA receptors.
    Moody et al.
    Toxicol.Lett., 1998;100-101:209
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Etomidate include:

1 Citations: Showing 1 - 1

  1. Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells.
    Authors: Rodgers Et al.
    Proc Natl Acad Sci U S A 2015;35:9707

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