Chemical Name: (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
Biological ActivityEtomidate is a general anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The interaction of the general anesthetic EtoM. with the γ-aminobutyric acid type A receptor is influenced by a single amino acid.
Belelli et al.
EtoM.: a new intravenous anesthetic induction agent.
Giese et al.
Distinct structural requirements for the direct and indirect actions of the anaesthetic EtoM. at GABAA receptors.
Moody et al.
Citations for Etomidate
The citations listed below are publications that use Tocris products. Selected citations for Etomidate include:
3 Citations: Showing 1 - 3
Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors.
Authors: Olander Et al.
EtoM. Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells.
Authors: Rodgers Et al.
Proc Natl Acad Sci U S A 2015;35:9707
Modulation of extrasynaptic THIP conductances by GABAA-receptor modulators in mouse neocortex.
Authors: Drasbek Et al.
J Neurophysiol 2007;97:2293
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