Home / PI 3-Kinase Inhibitors / ETP 45658

ETP 45658

Catalog #: 4702
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4702/10
4702/50
ETP 45658 | CAS No. 1198357-79-7 | PI 3-Kinase Inhibitors
1 Image
Description: Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

Chemical Name: 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ETP 45658 is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.

Technical Data

M.Wt:
311.34
Formula:
C16H17N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1198357-79-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for ETP 45658

The citations listed below are publications that use Tocris products. Selected citations for ETP 45658 include:

2 Citations: Showing 1 - 2

  1. Phenotypic screening for small molecules that protect �-cells from glucolipotoxicity.
    Authors: Small Et al.
    ACS Chem.Biol.  2022;17:1131
  2. Coadministration of dox. and etop. loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model.
    Authors: Maswadeh Et al.
    PLoS One  2015;10:2847

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ETP 45658

There are currently no reviews for this product. Be the first to review ETP 45658 and earn rewards!

Have you used ETP 45658?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.