ETP 45658

Catalog # Availability Size / Price Qty
4702/10
4702/50
ETP 45658 | CAS No. 1198357-79-7 | PI 3-Kinase Inhibitors
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Description: Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

Chemical Name: 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.

Technical Data

M.Wt:
311.34
Formula:
C16H17N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1198357-79-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for ETP 45658

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