Catalog Number: 0845
Chemical Name: 6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[4-amino- 5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt
Biological Activity
Potent inhibitor of L-glutamate uptake into synaptic vesicles. Also inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). P2X-selective purinoceptor antagonist.
Technical Data
  • M.Wt:
    960.82
  • Formula:
    C34H24N6Na4O14S4
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
    >95%
  • Storage:
    Store at RT
  • CAS No:
    314-13-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter.
    Roseth et al.
    J.Neurochem., 1995;65:96
  3. Evans blue antagonizes both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates desensitization.
    Price and Raymond
    Mol. Pharmacol., 1996;50:1665
  4. Differential modulation of AMPA receptor mediated currents by Evans Blue in postnatal rat hippocampal neurones.
    Schurmann et al.
    Br.J.Pharmacol., 1997;121:237
  5. P2-purinoceptor antagonists:II blockade of P2-purinoceptor subtypes and ecto-nucleotidase by compounds related to Evans blue and trypan blue.
    Wittenburg et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1996;354:491

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