EX 527

  ( 25 citations )    
Product Datasheet
Catalog Number:2780
Chemical Name:6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Product Details
Citations (25)
Biological Activity
Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for EX 527 include:

25 Citations: Showing 1 - 10
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  1. The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening.
    Authors: Deng Et al.
    Int J Nanomedicine  2017;12:3617
  2. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1.
    Authors: Sellner Et al.
    Acta Neuropathol Commun  2016;4:102
  3. Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment.
    Authors: Weinberg Et al.
    Front Neurosci  2015;9:430
  4. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia.
    Authors: Joo Et al.
    J Exp Med  2015;462:294
  5. Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival.
    Authors: Beier Et al.
    FASEB J  2015;29:2315
  6. SIRT1 deacetylates RORγt and enhances Th17 cell generation.
    Authors: Lim Et al.
    Mol Cell Biol  2015;212:607
  7. Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.
    Authors: Fan Et al.
    PLoS One  2014;9:e108514
  8. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
    Authors: Jiang and Zsombok
    Front Neurosci  2014;7:270
  9. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells.
    Authors: Akimova Et al.
    Mucosal Immunol  2014;7:1209
  10. Interferon regulatory factor 9 is critical for neointima formation following vascular injury.
    Authors: Zhang Et al.
    Nat Commun  2014;5:5160
  11. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke.
    Authors: Chen Et al.
    J Neurosci  2014;34:11897
  12. Novel role of silent information regulator 1 in acute endothelial cell oxidative stress injury.
    Authors: Li Et al.
    Biochim Biophys Acta  2014;1842:2246
  13. Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut.
    Authors: Caruso Et al.
    Mucosal Immunol  2014;
  14. Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance.
    Authors: Gu Et al.
    PLoS One  2013;8:e74050
  15. SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.
    Authors: Yan Et al.
    J Cereb Blood Flow Metab  2013;33:396
  16. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
    Authors: Armour Et al.
    Proc Natl Acad Sci U S A  2013;33:1487
  17. Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins.
    Authors: Pietrocola Et al.
    Cell Cycle  2012;11:3851
  18. Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate.
    Authors: Cottam Et al.
    Autophagy  2011;7:1335
  19. Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
    Authors: Paffett Et al.
    Vascul Pharmacol  2011;56:64
  20. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
    Authors: Peng Et al.
    Mol Cell Biol  2011;31:4720
  21. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance.
    Authors: Liu Et al.
    J Biol Chem  2011;286:9856
  22. Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.
    Authors: Kumar Et al.
    Front Mol Neurosci  2011;108:3636
  23. Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity.
    Authors: Dietrich Et al.
    J Neurosci  2010;30:11815
  24. Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation.
    Authors: Xie Et al.
    J Biol Chem  2009;284:28762
  25. STAT3 inhibition of gluconeogenesis is downregulated by SirT1.
    Authors: Nie Et al.
    Nat Cell Biol  2009;11:492
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