EX 527

Tocris Bioscience | Catalog # 2780

Selective SIRT1 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective SIRT1 inhibitor
View all Class III Histone Deacetylases Inhibitors »

Product Description

EX 527 is a selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). In an animal model of Huntington's disease, EX 527 rescues neuronal degeneration, extends lifespan, reduces huntingtin inclusions and prevents ventricular enlargement. EX 527 enhances p53 acetylation in response to DNA damaging agents. Orally bioavailable and brain penetrant.

Product Specifications for EX 527

Molecular Weight

248.71

Formula

C13H13ClN2O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

CAS Number

49843-98-3

PubChem ID

5113032

InChI Key

FUZYTVDVLBBXDL-UHFFFAOYSA-N

SMILES

ClC1=CC=C(NC3=C2CCCC3C(N)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.65 75
Ethanol 12.44 50

Preparing Stock Solutions for EX 527

The following data is based on the product molecular weight 248.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.36 mL 26.80 mL 53.61 mL
3.75 mM 1.07 mL 5.36 mL 10.72 mL
7.5 mM 0.54 mL 2.68 mL 5.36 mL
37.5 mM 0.11 mL 0.54 mL 1.07 mL

Calculators

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Product Documents for EX 527

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EX 527

For research use only

Customer Reviews for EX 527 (1)

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  • Works well in hepatocellular carcinoma cell lines
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HepG2, and Huh,
    Verified Customer | Posted 11/30/2022
    Dissolved in DMSO and used in hepatocellular carcinoma cell lines at a concentration of 50-100 uM.
    EX 527 2780

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