EX 527

  ( 25 citations )    
Product Datasheet
Catalog Number:2780
Chemical Name:6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Product Details
Citations (25)
Reviews
Biological Activity
Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.
Technical Data
  • M.Wt:
    248.71
  • Formula:
    C13H13ClN2O
  • Solubility:
    Soluble to 75 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    49843-98-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for EX 527 include:

25 Citations: Showing 1 - 10
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  1. The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening.
    Authors: Deng Et al.
    Int J Nanomedicine  2017;12:3617
  2. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1.
    Authors: Sellner Et al.
    Acta Neuropathol Commun  2016;4:102
  3. Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment.
    Authors: Weinberg Et al.
    Front Neurosci  2015;9:430
  4. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia.
    Authors: Joo Et al.
    J Exp Med  2015;462:294
  5. Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival.
    Authors: Beier Et al.
    FASEB J  2015;29:2315
  6. SIRT1 deacetylates RORγt and enhances Th17 cell generation.
    Authors: Lim Et al.
    Mol Cell Biol  2015;212:607
  7. Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.
    Authors: Fan Et al.
    PLoS One  2014;9:e108514
  8. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
    Authors: Jiang and Zsombok
    Front Neurosci  2014;7:270
  9. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells.
    Authors: Akimova Et al.
    Mucosal Immunol  2014;7:1209
  10. Interferon regulatory factor 9 is critical for neointima formation following vascular injury.
    Authors: Zhang Et al.
    Nat Commun  2014;5:5160
  11. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke.
    Authors: Chen Et al.
    J Neurosci  2014;34:11897
  12. Novel role of silent information regulator 1 in acute endothelial cell oxidative stress injury.
    Authors: Li Et al.
    Biochim Biophys Acta  2014;1842:2246
  13. Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut.
    Authors: Caruso Et al.
    Mucosal Immunol  2014;
  14. Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance.
    Authors: Gu Et al.
    PLoS One  2013;8:e74050
  15. SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.
    Authors: Yan Et al.
    J Cereb Blood Flow Metab  2013;33:396
  16. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
    Authors: Armour Et al.
    Proc Natl Acad Sci U S A  2013;33:1487
  17. Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins.
    Authors: Pietrocola Et al.
    Cell Cycle  2012;11:3851
  18. Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate.
    Authors: Cottam Et al.
    Autophagy  2011;7:1335
  19. Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
    Authors: Paffett Et al.
    Vascul Pharmacol  2011;56:64
  20. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
    Authors: Peng Et al.
    Mol Cell Biol  2011;31:4720
  21. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance.
    Authors: Liu Et al.
    J Biol Chem  2011;286:9856
  22. Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.
    Authors: Kumar Et al.
    Front Mol Neurosci  2011;108:3636
  23. Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity.
    Authors: Dietrich Et al.
    J Neurosci  2010;30:11815
  24. Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation.
    Authors: Xie Et al.
    J Biol Chem  2009;284:28762
  25. STAT3 inhibition of gluconeogenesis is downregulated by SirT1.
    Authors: Nie Et al.
    Nat Cell Biol  2009;11:492
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