Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione
Biological ActivityExemestane is an irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor.
Wang and Chen
Cancer Res., 2006;66:10281
Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter?
Miller et al.
Exemestane (FCE 24304), a new steroidal aromatase inhibitor.
di Salle et al.
J.Steroid Biochem.Molec.Bio., 1992;43:137
The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats.
Goss et al.
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