Catalog Number: 3759
Alternate Names: FCE 24304, EXE
Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione
Biological Activity
Irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.
Technical Data
  • M.Wt:
    296.4
  • Formula:
    C20H24O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    107868-30-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. The steroidal aromatase inhibitor exemestane prevents bone loss in ovariectomized rats.
    Goss et al.
    Bone, 2004;34:384
  2. Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor.
    Wang and Chen
    Cancer Res., 2006;66:10281
  3. Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter?
    Miller et al.
    Oncologist, 2008;13:829
  4. Exemestane (FCE 24304), a new steroidal aromatase inhibitor.
    di Salle et al.
    J.Steroid Biochem.Molec.Bio., 1992;43:137

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