Catalog # Availability Size / Price Qty
Exemestane | CAS No. 107868-30-4 | Cytochrome P450 Inhibitors
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Description: Steroidal aromatase (CYP19) inhibitor
Alternative Names: FCE 24304, EXE

Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione

Purity: ≥99%

Product Details

Biological Activity

Exemestane is an irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

Technical Data

Soluble to 100 mM in DMSO and to 75 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor.
    Wang and Chen
    Cancer Res., 2006;66:10281
  2. Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter?
    Miller et al.
    Oncologist, 2008;13:829
  3. Exemestane (FCE 24304), a new steroidal aromatase inhibitor.
    di Salle et al.
    J.Steroid Biochem.Molec.Bio., 1992;43:137
  4. The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats.
    Goss et al.
    Bone, 2004;34:384

Product Datasheets

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