Exemestane

Catalog # Availability Size / Price Qty
3759/10
3759/50
Exemestane | CAS No. 107868-30-4 | Cytochrome P450 Inhibitors
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Description: Steroidal aromatase (CYP19) inhibitor
Alternative Names: FCE 24304, EXE

Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione

Purity: ≥99%

Product Details
Reviews

Biological Activity

Irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

Technical Data

M.Wt:
296.4
Formula:
C20H24O2
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
107868-30-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor.
    Wang and Chen
    Cancer Res., 2006;66:10281
  2. Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter?
    Miller et al.
    Oncologist, 2008;13:829
  3. Exemestane (FCE 24304), a new steroidal aromatase inhibitor.
    di Salle et al.
    J.Steroid Biochem.Molec.Bio., 1992;43:137
  4. The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats.
    Goss et al.
    Bone, 2004;34:384

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