FADD Antibody

Novus Biologicals | Catalog # NBP1-45552

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Monkey, Primate

Cited:

Human, Mouse

Applications

Validated:

Western Blot, Immunoprecipitation

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all FADD Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide surrounding amino acid 128 of human FADD.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

23 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

This product is manufactured by Abcam and distributed by Novus Biologicals. (Abcam Catalog Number: ab24533)

Scientific Data Images for FADD Antibody

Western Blot: FADD Antibody [NBP1-45552]

Western Blot: FADD Antibody [NBP1-45552]

Western Blot: FADD Antibody [NBP1-45552] - Analysis of FADD expression with Jurkat cell lysates (Lane 1, 2).

Applications for FADD Antibody

Application
Recommended Usage

Western Blot

0.5 - 4 ug/mL

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2), 5 mM EDTA, 50% glycerol, 0.5% BSA

Preservative

0.03% Proclin 300

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: FADD

Fas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis.

Long Name

Fas-associated Death Domain Protein

Alternate Names

MORT1

Entrez Gene IDs

8772 (Human)

Gene Symbol

FADD

UniProt

Q13158

Additional FADD Products

Product Documents for FADD Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FADD Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs

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Associated Pathways

Apoptosis Signaling Pathway Apoptosis Signaling Pathway Thumbnail