CXCR4 antagonist (IC50
= 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50
= 21 nM for both strains).
XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr]
Soluble to 2 mg/ml in water
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131
Tamamura et al.
Potent CXCR4 antagonists containing amidine type peptide bond isosteres.
Inokuchi et al.
ACS Med.Chem.Lett., 2011;2:477