FE65 Antibody

Novus Biologicals | Catalog # NB100-41392

Novus Biologicals
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Key Product Details

Species Reactivity

Mouse

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all FE65 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-GSLKPKRLGAHTP corresponding to C-Terminus according to NP_001155.1, NP_663722.1.

Reactivity Notes

Expected from sequence similarity: Human.

Specificity

This antibody is expected to recognise both reported isoforms (NP_001155.1 and NP_663722.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for FE65 Antibody

Western Blot: FE65 Antibody [NB100-41392]

Western Blot: FE65 Antibody [NB100-41392]

Western Blot: FE65 Antibody [NB100-41392] - (0.1ug/ml) staining of NIH/3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for FE65 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:128000

Western Blot

0.1 - 0.3 ug/ml
Application Notes
WB: Approx. 100 kDa band observed in lysates of NIH/3T3 and HeLa (PMID: 9685356).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: FE65

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.

Alternate Names

adaptor protein FE65a2, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), amyloid beta A4 precursor protein-binding, family B, member 1, Fe65, FE65amyloid beta A4 precursor protein-binding family B member 1, MGC:9072, Protein Fe65, RIR, stat-like protein

Entrez Gene IDs

322 (Human); 11785 (Mouse)

Gene Symbol

APBB1

UniProt

NP_001155.1 (Human)

Additional FE65 Products

Product Documents for FE65 Antibody

Certificate of Analysis

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Product Specific Notices for FE65 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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