Catalog Number: 1396
Alternate Names: 4-HPR
Chemical Name: N-(4-Hydroxyphenyl)retinamide
Biological Activity
Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Technical Data
  • M.Wt:
    391.55
  • Formula:
    C26H33NO2
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    65646-68-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat.
    Le Doze et al.
    Drug Metab.Dispos., 2000;28:205
  2. Fenretinide and its relation to cancer.
    Ulukaya and Wood
    Cancer Treat.Rev., 1999;25:229
  3. Antioxidant properties of N-(4-hydroxyphenyl)retinamide (fenretinide).
    Takahashi
    Biol.Pharm.Bull., 2000;23:222
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fenretinide include:

2 Citations: Showing 1 - 2
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  1. Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
    Authors: Seidensaal Et al.
    Am J Pathol 2015;14:204
  2. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.
    Authors: Johansson Et al.
    Nat Commun 2013;4:2175
Tocris Small Molecules
Description Application Cat# Citations Images  

Fenretinide - d4

5525  
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