Ferrostatin 1

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5180/10
5180/50
Ferrostatin 1 | CAS No. 347174-05-4 | Ferroptosis Inhibitors
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Description: Selective inhibitor of erastin induced ferroptosis

Chemical Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Ferrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

Technical Data

M.Wt:
262.35
Formula:
C15H22N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
347174-05-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Ferrostatin 1

The citations listed below are publications that use Tocris products. Selected citations for Ferrostatin 1 include:

1 Citation: Showing 1 - 1

  1. Metadherin enhances vulnerability of cancer cells to ferroptosis.
    Authors: Bi Et al.
    Cell Death Dis  2019;10:682

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