Ferrostatin 1

Tocris Bioscience | Catalog # 5180

Selective inhibitor of erastin induced ferroptosis
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of erastin induced ferroptosis
View all Ferroptosis Inhibitors »

Product Description

Ferrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

Product Specifications for Ferrostatin 1

Molecular Weight

262.35

Formula

C15H22N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Ethyl 3-amino-4-(cyclohexylamino)benzoate

CAS Number

347174-05-4

PubChem ID

4068248

InChI Key

UJHBVMHOBZBWMX-UHFFFAOYSA-N

SMILES

O=C(OCC)C1=CC(N)=C(NC2CCCCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.23 100
Ethanol 26.23 100

Preparing Stock Solutions for Ferrostatin 1

The following data is based on the product molecular weight 262.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.81 mL 19.06 mL 38.12 mL
5 mM 0.76 mL 3.81 mL 7.62 mL
10 mM 0.38 mL 1.91 mL 3.81 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for Ferrostatin 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ferrostatin 1

For research use only

Customer Reviews for Ferrostatin 1 (1)

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  • Ferroptosis-related studies
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/13/2022
    Combinatorial treatments of Ferrostatin 1 with other chemotherapeutic drugs were performed to elucidate the dependence of the latter on the induction of ferroptosis. Results were consistent.

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