Chemical Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate
Biological Activity Selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C
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