Chemical Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate
Biological ActivityFerrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.
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Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Dixon et al.
FerroSTAT inhibit oxidative lipid damage and cell death in diverse disease models.
Skouta et al.
Iron-dependent cell death of hepatocellular carcinoma cells exposed to sora.
Louandre et al.
Citation for Ferrostatin 1
The citations listed below are publications that use Tocris products. Selected citations for Ferrostatin 1 include:
1 Citation: Showing 1 - 1
Metadherin enhances vulnerability of cancer cells to ferroptosis.
Authors: Bi Et al.
Cell Death Dis 2019;10:682
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