Catalog Number: 5180
Chemical Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate
Biological Activity
Selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ferroptosis: an iron-dependent form of nonapoptotic cell death.
    Dixon et al.
    Cell, 2012;149:1060
  2. Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib.
    Louandre et al.
    Int.J.Cancer, 2013;133:1732
  3. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.
    Skouta et al.
    J.Am.Chem.Soc., 2014;136:4551
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