Selective inhibitor of erastin
induced ferroptosis (EC50
= 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.
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All Tocris products are intended for laboratory research use only.
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Dixon et al.
Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib.
Louandre et al.
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.
Skouta et al.