Fexofenadine hydrochloride

Key Product Details

Product Description

Fexofenadine hydrochloride is a selective histamine H₁ receptor antagonist (pK_i = 8.1). Active metabolite of Terfenadine (Cat. No. 3948) that displays non-sedating antiallergic effects. Fexofenadine hydrochloride counteracts histamine mediated immune suppression and improves immunotherapy response.

Product Specifications for Fexofenadine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Fexofenadine hydrochloride

The following data is based on the product molecular weight 538.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.72 mL	18.58 mL	37.17 mL
2.5 mM	0.74 mL	3.72 mL	7.43 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
25 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Li The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell 2022 PMID: 34822775
• Sakairi Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 2005 PMID: 16037679
• Gillard and Chatelaine Changes in pH differently affect the binding properties of histamine H₁ receptor antagonists. Eur.J.Pharmacol. 2006 PMID: 16388798
• Markham and Wagstaff Fexofenadine. Drugs 1998 PMID: 9506246

Product Documents for Fexofenadine hydrochloride