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Fexofenadine hydrochloride

Catalog #: 2429
1 Citation Datasheet / COA / SDS

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2429 has been discontinued.
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Fexofenadine hydrochloride | CAS No. 153439-40-8 | Histamine H1 Receptor Antagonists
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Description: H1 receptor antagonist; non-sedating antiallergic agent
Alternative Names: MDL 16455,Terfenidine

Chemical Name: α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneacetic acid hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Fexofenadine hydrochloride is a selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of Terfenadine (Cat. No. 3948) that displays non-sedating antiallergic effects. Fexofenadine hydrochloride counteracts histamine mediated immune suppression and improves immunotherapy response.

Technical Data

M.Wt:
538.12
Formula:
C32H39NO4.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
153439-40-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Fexofenadine.
    Markham and Wagstaff
    Drugs, 1998;55:269
  2. Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.
    Sakairi et al.
    Pharmacology, 2005;75:76
  3. Changes in pH differently affect the binding properties of histamine H1 receptor antagonists.
    Gillard and Chatelaine
    Eur.J.Pharmacol., 2006;530:205

Product Datasheets

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Citation for Fexofenadine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Fexofenadine hydrochloride include:

1 Citation: Showing 1 - 1

  1. A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo " connect".
    Authors: Won Et al.
    Mucosal Immunol  2013;53:982

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