receptor antagonist. Also blocks KV
11.1 (hERG) and Kir
) channels (IC50
values are 204 nM and 1.2 μ
M respectively). Inhibits the delayed rectifier K+
) in guinea pig ventricular myocytes (IC50
= 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Loratadine blockade of K+ channels in human heart: comparison with terfenadine under physiological conditions.
Mechanism of terfenadine block of ATP-sensitive K+ channels.
Zunkler et al.
State dependent dissociation of HERG channel inhibitors.
Stork et al.
The citations listed below are publications that use Tocris products. Selected citations for Terfenadine include:
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