Terfenadine

Tocris Bioscience | Catalog # 3948

H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker
Tocris Bioscience

Key Product Details

Description

H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker
View all Histamine H1 Receptor Antagonists »

Product Description

Terfenadine is a histamine H1 receptor antagonist. Also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 μM respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo.

Product Specifications for Terfenadine

Molecular Weight

471.67

Formula

C32H41NO2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

CAS Number

50679-08-8

PubChem ID

5405

InChI Key

GUGOEEXESWIERI-UHFFFAOYSA-N

SMILES

OC(C3=CC=CC=C3)(C4=CC=CC=C4)C1CCN(CCCC(O)C2=CC=C(C(C)(C)C)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.17 100
Ethanol 11.79 25

Preparing Stock Solutions for Terfenadine

The following data is based on the product molecular weight 471.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.60 mL 21.20 mL
5 mM 0.42 mL 2.12 mL 4.24 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for Terfenadine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Terfenadine

For research use only

Customer Reviews for Terfenadine (1)

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  • Terfenadine was used to assess its action on BK channels
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 12/03/2018
    Terfenadine was used to assess its action on BK channels, which are Calcium activated voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. Results were reliable and reproducible.
    Terfenadine 3948

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