Home / Histamine H1 Receptor Antagonists / Terfenadine

Terfenadine

Catalog #: 3948
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3948/50

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Terfenadine | CAS No. 50679-08-8 | Histamine H1 Receptor Antagonists
1 Image
Description: H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

Chemical Name: α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Terfenadine is a histamine H1 receptor antagonist. Also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 μM respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo.

Technical Data

M.Wt:
471.67
Formula:
C32H41NO2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
50679-08-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Research

5-HT4 agonist; stimulates intestinal ACh release
Cat # 1695
HIV protease inhibitor
Cat # 4418
Blocks sodium and potassium channels
Cat # 4108
Potent, reversible BTK inhibitor
Cat # 6965
Pregnane X receptor agonist; antibiotic
Cat # 5359
Nrf2 activator; inhibits Nrf2/Keap1 interaction
Cat # 5707
α7 nAChR partial agonist
Cat # 3518
Potent and selective GlyT1 inhibitor
Cat # 5308
Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors
Cat # 1636
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
Cat # 3757
MAGE-A11 inhibitor disrupts MAGE-A11:PCF11 interaction
Cat # 7542
Secretory phospholipase A2 (sPLA2) inhibitor
Cat # 2522
Selective 15-lipoxygenase inhibitor
Cat # 2850
Potent and selective non-peptide AT1 antagonist
Cat # 1849
Selective BRD7 and BRD9 inhibitor
Cat # 5496
Selective inhibitor of GAT-1
Cat # 1296
High affinity 5-HT6 antagonist
Cat # 3326
Potent liver X receptor (LXR) agonist; also CAR inverse agonist
Cat # 2373
α3β2 full agonist; also α3β4 partial agonist
Cat # 4831

Complete Your Experiment

Human Histamine H1 R (AAH60802) VersaClone cDNA
Cat # RDC0341
Mouse Histamine H1 R (NP_032311) VersaClone cDNA
Cat # RDC0392

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Terfenadine

The citations listed below are publications that use Tocris products. Selected citations for Terfenadine include:

3 Citations: Showing 1 - 3

  1. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia.
    Authors: Pérez-G?mez Et al.
    Nat Commun  2018;9:5272
  2. Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice.
    Authors: Klingerman Et al.
    Schizophr Bull  2014;40:327
  3. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.
    Authors: Francis Et al.
    Gut  2012;61:753

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Human Histamine H1 R (AAH60802) VersaClone cDNA

RDC0341

Mouse Histamine H1 R (NP_032311) VersaClone cDNA

RDC0392

Reviews for Terfenadine

There are currently no reviews for this product. Be the first to review Terfenadine and earn rewards!

Have you used Terfenadine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.