Chemical Name: α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
Biological ActivityTerfenadine is a histamine H1 receptor antagonist. Also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 μM respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Loratadine blockade of K+ channels in human heart: comparison with terfenadine under physiological conditions.
Mechanism of terfenadine block of ATP-sensitive K+ channels.
Zunkler et al.
Citations for Terfenadine
The citations listed below are publications that use Tocris products. Selected citations for Terfenadine include:
3 Citations: Showing 1 - 3
A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia.
Authors: Pérez-G?mez Et al.
Nat Commun 2018;9:5272
Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice.
Authors: Klingerman Et al.
Schizophr Bull 2014;40:327
Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.
Authors: Francis Et al.
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