FICZ
Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Purity: ≥95%
Biological Activity
FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Complete Your Experiment
Background References
-
AhR sensing of bacterial pigments regulates antibacterial defence.
Moura-Alves et al.
Nature, 2014;512:387 -
Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands.
Rannug et al.
Chem.Biol., 1995;2:841 -
The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.
Wincent et al.
J.Biol.Chem., 2009;284:2690
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for FICZ
The citations listed below are publications that use Tocris products. Selected citations for FICZ include:
1 Citation: Showing 1 - 1
-
Modeling the binding of diverse ligands within the Ah receptor ligand binding domain.
Authors: Tagliabue Et al.
Sci Rep 2019;9:10693
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for FICZ
There are currently no reviews for this product. Be the first to review FICZ and earn rewards!
Have you used FICZ?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
