Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Biological ActivityFICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
AhR sensing of bacterial pigments regulates antibacterial defence.
Moura-Alves et al.
Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands.
Rannug et al.
The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.
Wincent et al.
Citation for FICZ
The citations listed below are publications that use Tocris products. Selected citations for FICZ include:
1 Citation: Showing 1 - 1
Modeling the binding of diverse ligands within the Ah receptor ligand binding domain.
Authors: Tagliabue Et al.
Sci Rep 2019;9:10693
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