Catalog Number: 5304
Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Biological Activity
High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands.
    Rannug et al.
    Chem.Biol., 1995;2:841
  2. The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.
    Wincent et al.
    J.Biol.Chem., 2009;284:2690
  3. AhR sensing of bacterial pigments regulates antibacterial defence.
    Moura-Alves et al.
    Nature, 2014;512:387
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