Chemical Name: 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Biological ActivityHigh affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands.
Rannug et al.
The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.
Wincent et al.
AhR sensing of bacterial pigments regulates antibacterial defence.
Moura-Alves et al.
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