FICZ

Key Product Details

Product Description

FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (K_d = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Product Specifications for FICZ

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FICZ

The following data is based on the product molecular weight 284.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

9 7 6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.07 mL	70.35 mL	140.69 mL
1.25 mM	2.81 mL	14.07 mL	28.14 mL
2.5 mM	1.41 mL	7.03 mL	14.07 mL
12.5 mM	0.28 mL	1.41 mL	2.81 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Wincent The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 2009 PMID: 19054769
• Moura-Alves AhR sensing of bacterial pigments regulates antibacterial defence. Nature 2014 PMID: 25119038
• Rannug Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 1995 PMID: 8807817

Product Documents for FICZ