FIIN 1 hydrochloride

Tocris Bioscience | Catalog # 4002

Potent, irreversible FGFR inhibitor
Tocris Bioscience
Discontinued Product
4002 has been discontinued. View all FGF Receptor Inhibitors products.

Key Product Details

Description

Potent, irreversible FGFR inhibitor
View all FGF Receptor Inhibitors »

Product Description

FIIN 1 hydrochloride is a potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).

Product Specifications for FIIN 1 hydrochloride

Molecular Weight

693.06

Formula

C32H39Cl2N7O4

Storage

Store at -20°C

Purity

≥96% (HPLC)

Chemical Name

N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide

CAS Number

1256152-35-8

PubChem ID

90488902

InChI Key

IQLGDXNKTDKSMY-UHFFFAOYSA-N

SMILES

CCN(CC)CCCCNC1=NC=C2C(N(CC3=CC=CC(NC(C=C)=O)=C3)C(N(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C2)=O)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 69.31 100
Ethanol 69.31 100

Preparing Stock Solutions for FIIN 1 hydrochloride

The following data is based on the product molecular weight 693.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.21 mL 14.43 mL
5 mM 0.29 mL 1.44 mL 2.89 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for FIIN 1 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FIIN 1 hydrochloride

For research use only

Citations for FIIN 1 hydrochloride

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