Chemical Name: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Biological ActivitySelective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Also promotes mESC self-renewal, facilitates the conversion of mouse epiblast stem cells to an earlier pluripotency state and inhibts differentiation of miPSCs to cardiomyocytes. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells.
Bansal et al.
1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bla
Miyake et al.
Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma.
Trudel et al.
The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo.
Pardo et al.
Cancer Res., 2010;69:8645
Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules.
Zhou et al.
Capture of authentic embryonic stem cells from rat blastocysts.
Buehr et al.
Citations for PD 173074
The citations listed below are publications that use Tocris products. Selected citations for PD 173074 include:
20 Citations: Showing 1 - 10
Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart.
Authors: Bise Et al.
NPJ Regen Med 2019;4:2
IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development.
Authors: Yuan Et al.
Cell Death Dis 2019;10:63
Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism.
Authors: Takata Et al.
Nat Commun 2017;8:1339
Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.
Authors: Lichtenberger Et al.
Nat Commun 2016;7:10537
FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration.
Authors: Nacu Et al.
A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation.
Authors: Benzina Et al.
Stem Cells Int 2015;72:3559
Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion.
Authors: Knuchel Et al.
A Molecular atlas of Xenopus respiratory system development.
Authors: Rankin Et al.
PLoS One 2015;244:69
Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.
Authors: Yang Et al.
Dev Dyn 2015;2015:270428
Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis.
Authors: MacKenzie Et al.
Respir Res 2015;16:83
The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.
Authors: Saito Et al.
BMC Cancer 2015;15:82
PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR.
Authors: Anreddy Et al.
Generation of the epicardial lineage from human pluripotent stem cells.
Authors: Witty Et al.
Nat Biotechnol 2014;32:1026
Modulation of pluripotency in the porcine embryo and iPS cells.
Authors: Rodríguez Et al.
Acta Pharm Sin B 2012;7:e49079
Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development.
Authors: Gibson Et al.
PLoS One 2012;7:e33828
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Authors: Wilson Et al.
The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
Authors: Borroto-Escuela Et al.
J Neurosci 2012;32:6295
Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
Authors: Rankin Et al.
Cell Mol Life Sci 2012;139:3010
Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states.
Authors: Cho Et al.
J Biol Chem 2012;139:2866
Prolonged FGF signaling is necessary for lung and liver induction in Xenopus.
Authors: Shifley Et al.
BMC Dev Biol 2012;12:27
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Mice received a dose of 25 mg per kg body weight PD173074 dissolved in acetone or vehicle only topically onto the back skin.