Catalog Number: 3044
Chemical Name: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Biological Activity
Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
Technical Data
  • M.Wt:
    523.67
  • Formula:
    C28H41N7O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    219580-11-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells.
    Bansal et al.
    J.Neurosci.Res., 2003;74:486
  2. 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bla
    Miyake et al.
    J.Pharmacol.Exp.Ther., 2010;332:795
  3. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma.
    Trudel et al.
    Neoplasia, 2004;103:3521
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 173074 include:

15 Citations: Showing 1 - 10
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  1. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation.
    Authors: Benzina Et al.
    Stem Cells Int 2015;72:3559
  2. Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion.
    Authors: Knuchel Et al.
    Development 2015;6:14300
  3. A Molecular atlas of Xenopus respiratory system development.
    Authors: Rankin Et al.
    PLoS One 2015;244:69
  4. Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.
    Authors: Yang Et al.
    Dev Dyn 2015;2015:270428
  5. Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis.
    Authors: MacKenzie Et al.
    Respir Res 2015;16:83
  6. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.
    Authors: Saito Et al.
    BMC Cancer 2015;15:82
  7. PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR.
    Authors: Anreddy Et al.
    Development 2014;4:202
  8. Generation of the epicardial lineage from human pluripotent stem cells.
    Authors: Witty Et al.
    Nat Biotechnol 2014;32:1026
  9. Modulation of pluripotency in the porcine embryo and iPS cells.
    Authors: Rodríguez Et al.
    Acta Pharm Sin B 2012;7:e49079
  10. Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development.
    Authors: Gibson Et al.
    PLoS One 2012;7:e33828
  11. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson Et al.
    Nature 2012;487:505
  12. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
    Authors: Borroto-Escuela Et al.
    J Neurosci 2012;32:6295
  13. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
    Authors: Rankin Et al.
    Cell Mol Life Sci 2012;139:3010
  14. Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states.
    Authors: Cho Et al.
    J Biol Chem 2012;139:2866
  15. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus.
    Authors: Shifley Et al.
    BMC Dev Biol 2012;12:27
Expand to show all 15 Citations

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