FK 228

Tocris Bioscience | Catalog # 3515

Potent and selective class I histone deacetylase inhibitor; antitumor
Tocris Bioscience

Key Product Details

Description

Potent and selective class I histone deacetylase inhibitor; antitumor

Alternative Names

Depsipeptide,FR 901228,Romidepsin
View all Class I Histone Deacetylases Inhibitors »

Product Description

FK 228 is a potent and selective inhibitor of class I histone deacetylases (HDACs) (IC50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Romidepsin is reviewed on the Chemical Probes website.

Product Specifications for FK 228

Molecular Weight

540.70

Formula

C24H36N4O6S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5) disulfide

CAS Number

128517-07-7

PubChem ID

5352062

InChI Key

OHRURASPPZQGQM-GCCNXGTGSA-N

SMILES

O=C([C@H]([C@H](C)C)NC(/C(NC([C@@H]2NC([C@@H]([C@H](C)C)N1)=O)=O)=C/C)=O)O[C@H](/C=C/CCSSC2)CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.41 10

Preparing Stock Solutions for FK 228

The following data is based on the product molecular weight 540.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.49 mL 92.47 mL 184.95 mL
0.5 mM 3.70 mL 18.49 mL 36.99 mL
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.70 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for FK 228

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FK 228

For research use only

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