Chemical Name: (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
Biological ActivityFK 888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist.
Fujii et al.
Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.
Murai et al.
Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for cloned rat and human tachykinin receptors.
Aramori et al.
Citation for FK 888
The citations listed below are publications that use Tocris products. Selected citations for FK 888 include:
1 Citation: Showing 1 - 1
Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons.
Authors: Mondal Et al.
PLoS One 2013;8:e60365
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