Selective, high affinity tachykinin NK1
receptor antagonist (Ki
= 0.69 nM) that displays 320-fold selectivity for human over rat NK1
receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC50
= 32 nM) and inhibits substance P-induced airway constriction in vivo
following i.v. and oral administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of Astellas Pharma Inc.
Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for cloned rat and human tachykinin receptors.
Aramori et al.
Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist.
Fujii et al.
Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.
Murai et al.
The citations listed below are publications that use Tocris products. Selected citations for FK 888 include:
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