FK 888

Key Product Details

Product Description

FK 888 is a selective, high affinity tachykinin NK₁ receptor antagonist (K_i = 0.69 nM) that displays 320-fold selectivity for human over rat NK₁ receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC₅₀ = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Product Specifications for FK 888

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FK 888

The following data is based on the product molecular weight 588.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.70 mL	8.49 mL	16.99 mL
5 mM	0.34 mL	1.70 mL	3.40 mL
10 mM	0.17 mL	0.85 mL	1.70 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

• Murai Effects of an NK₁ receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin. Eur.J.Pharmacol. 1993 PMID: 7686493
• Aramori Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for cloned rat and human tachykinin receptors. Eur.J.Pharmacol. 1994 PMID: 7531648
• Fujii Pharmacological profile of a high affinity dipeptide NK₁ receptor antagonist. Br.J.Pharmacol. 1992 PMID: 1282073

Product Documents for FK 888