Fludarabine

Catalog # Availability Size / Price Qty
3495/10
3495/50
Fludarabine | CAS No. 21679-14-1 | DNA, RNA and Protein Synthesis Inhibitors
1 Image
Description: Purine analog; inhibits DNA synthesis

Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

Technical Data

M.Wt:
285.23
Formula:
C10H12FN5O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
21679-14-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Fludarabine

The citations listed below are publications that use Tocris products. Selected citations for Fludarabine include:

2 Citations: Showing 1 - 2

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Fludarabine

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Fludarabine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


STAT1 inhibitor in IFN beta signaling
By Richa Rani on 01/04/2018
Species: Mouse

I used it to check its effect on drug stimulated hepatic stellate cell and its signaling.


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.