Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50
= 1.54 μ
M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo
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In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia.
Bellosillo et al.
Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo.
Meng et al.
Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation.
Torella et al.
Am.J.Physiol.Heart Circ.Physiol., 2007;292:H2935
Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.
Frank et al.
The citations listed below are publications that use Tocris products. Selected citations for Fludarabine include:
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