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Fludarabine

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3495
Chemical Name:9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Product Details
Citations (2)
Reviews
Biological Activity
Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.
Technical Data
  • M.Wt:
    285.23
  • Formula:
    C10H12FN5O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    21679-14-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fludarabine include:

2 Citations: Showing 1 - 2
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  1. Diverse intracellular pathogens activate type III interferon expression from peroxisomes.
    Authors: Odendall Et al.
    Nat Immunol  2014;15:717
  2. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641

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Average Rating: 5 (Based on 1 review)

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   Mouse Richa Rani 01/04/2018
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