Catalog Number: 3495
Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Biological Activity
Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.
Technical Data
  • M.Wt:
    285.23
  • Formula:
    C10H12FN5O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    21679-14-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia.
    Bellosillo et al.
    Blood, 1999;94:2836
  2. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo.
    Meng et al.
    Eur.J.Haematol., 2007;79:486
  3. Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation.
    Torella et al.
    Am.J.Physiol.Heart Circ.Physiol., 2007;292:H2935
  4. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.
    Frank et al.
    Nat.Med., 1999;5:444
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fludarabine include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Diverse intracellular pathogens activate type III interferon expression from peroxisomes.
    Authors: Odendall Et al.
    Nat Immunol 2014;15:717
  2. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One 2013;8:e78641

Have you used Fludarabine?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information