Fludarabine

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3495
Chemical Name:9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Product Details
Citations (2)
Reviews
Biological Activity
Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.
Technical Data
  • M.Wt:
    285.23
  • Formula:
    C10H12FN5O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    21679-14-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fludarabine include:

2 Citations: Showing 1 - 2
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  1. Diverse intracellular pathogens activate type III interferon expression from peroxisomes.
    Authors: Odendall Et al.
    Nat Immunol  2014;15:717
  2. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641

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Average Rating: 5 (Based on 1 review)

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