Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Biological ActivityPurine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.
Frank et al.
Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation.
Torella et al.
Am.J.Physiol.Heart Circ.Physiol., 2007;292:H2935
In vitro evaluation of fludar. in combination with cyclophosph. and/or mitoxan. in B-cell chronic lymphocytic leukemia.
Bellosillo et al.
Antitumor activity of fludar. against human multiple myeloma in vitro and in vivo.
Meng et al.
Citations for Fludarabine
The citations listed below are publications that use Tocris products. Selected citations for Fludarabine include:
2 Citations: Showing 1 - 2
Diverse intracellular pathogens activate type III IF. expression from peroxisomes.
Authors: Odendall Et al.
Nat Immunol 2014;15:717
RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
Authors: Robinson Et al.
PLoS One 2013;8:e78641
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Reviews for Fludarabine
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I used it to check its effect on drug stimulated hepatic stellate cell and its signaling.