Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
Biological ActivityNonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes.
White and Aylwin
Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase.
Chi et al.
Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons.
Tu et al.
Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells.
Foster et al.
Cell Calcium, 2009;45:384
Citations for Flufenamic acid
The citations listed below are publications that use Tocris products. Selected citations for Flufenamic acid include:
2 Citations: Showing 1 - 2
TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations
Authors: O'Malley Et al.
J Neurosci 2020;40:4813
Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.
Authors: Sun Et al.
Sci Rep 2014;4:4934
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Flufenamic Acid interaction with AKR1C4 protein was measured. The activity relation pattern observed.