Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
Biological ActivityNonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes.
White and Aylwin
Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase.
Chi et al.
Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons.
Tu et al.
Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells.
Foster et al.
Cell Calcium, 2009;45:384
Citation for Flufenamic acid
The citations listed below are publications that use Tocris products. Selected citations for Flufenamic acid include:
1 Citation: Showing 1 - 1
Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.
Authors: Sun Et al.
Sci Rep 2014;4:4934
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Flufenamic Acid interaction with AKR1C4 protein was measured. The activity relation pattern observed.