5 results for "Calcium-activated Chloride Channel Blockers" in Products
Calcium-activated Chloride Channel Blockers
Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin. TMEM16 (anoctamin) genes have been identified as pore-forming subunits for the channel.
CaCC have a variety of roles: in transepithelial salt transport; excitability in neurons, skeletal, cardiac and smooth muscle cells; acidification; cell cycle; oocyte fertilization; and ...
Inhibits calcium-sensitive chloride currents
| Chemical Name: | 5-Nitro-2-(3-phenylpropylamino)benzoic acid |
| Purity: | ≥98% |
Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker
| Chemical Name: | 2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide |
| Purity: | ≥98% |
Calcium-activated chloride channel (CaCC) inhibitor
| Chemical Name: | 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid |
| Purity: | ≥98% |
Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
| Chemical Name: | 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid |
| Purity: | ≥98% |
Potent TMEM16A (Anoctamin-1) blocker
| Chemical Name: | 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid |
| Purity: | ≥98% |
