Orally active, potent and competitive HMG-CoA reductase inhibitor (IC50
= 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro
= 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins.
Dansette et al.
Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes.
Yamamoto et al.
Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
Turner et al.
The citations listed below are publications that use Tocris products. Selected citations for Fluvastatin sodium include:
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