Fluvastatin sodium

Key Product Details

Product Description

Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor (IC₅₀ = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC₅₀ = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.

Product Specifications for Fluvastatin sodium

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Fluvastatin sodium

The following data is based on the product molecular weight 433.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.54 mL	23.07 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Yamamoto Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. J.Pharm.Pharmacol. 2001 PMID: 11273020
• Turner Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 2007 PMID: 18049315
• Dansette HMG-CoA reductase activity in human liver microsomes: comparative inhibition by STAT. Exp.Toxicol.Pathol. 2000 PMID: 10965989

Product Documents for Fluvastatin sodium