Fluvastatin sodium

  ( 4 citations )    
Product Datasheet
Catalog Number:3309
Chemical Name:(±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
Product Details
Citations (4)
Reviews
Biological Activity
Orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.
Technical Data
  • M.Wt:
    433.45
  • Formula:
    C24H25FNNaO4
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    93957-55-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fluvastatin sodium include:

4 Citations: Showing 1 - 4
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  1. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
    Authors: Park Et al.
    Nat Immunol  2016;17:914
  2. Fluvastatin suppresses native and recombinant human P2X4 receptor function.
    Authors: Li and Fountain
    Purinergic Signal  2012;8:311
  3. Studies on the antibacterial effects of statins--in vitro and in vivo.
    Authors: Bergman Et al.
    PLoS One  2011;6:e24394
  4. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.
    Authors: Vainio Et al.
    Am J Physiol Renal Physiol  2011;2:1176

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