Chemical Name: (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
Biological ActivityFluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
HMG-CoA reductase activity in human liver microsomes: comparative inhibition by STAT.
Dansette et al.
Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes.
Yamamoto et al.
Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
Turner et al.
Citations for Fluvastatin sodium
The citations listed below are publications that use Tocris products. Selected citations for Fluvastatin sodium include:
5 Citations: Showing 1 - 5
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Authors: Park Et al.
Nat Immunol 2016;17:914
Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
Authors: Rojo-Arreola Et al.
PLoS One 2014;9:e87594
Fluvastatin suppresses native and recombinant human P2X4 receptor function.
Authors: Li and Fountain
Purinergic Signal 2012;8:311
Studies on the antibacterial effects of STAT--in vitro and in vivo.
Authors: Bergman Et al.
PLoS One 2011;6:e24394
Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT.
Authors: Vainio Et al.
Am J Physiol Renal Physiol 2011;2:1176
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