Catalog Number: 3309
Chemical Name: (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
Biological Activity
Orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.
Technical Data
  • M.Wt:
    433.45
  • Formula:
    C24H25FNNaO4
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    93957-55-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins.
    Dansette et al.
    Exp.Toxicol.Pathol., 2000;52:145
  2. Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes.
    Yamamoto et al.
    J.Pharm.Pharmacol., 2001;53:227
  3. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.
    Turner et al.
    J.Cardiovasc.Pharmacol., 2007;50:458
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fluvastatin sodium include:

1 Citations: Showing 1 - 1

  1. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.
    Authors: Vainio Et al.
    Am J Physiol Renal Physiol 2011;2:1176

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